402516
1H-吡唑-1-甲脒 盐酸盐
99%
别名:
1H-吡唑-1-甲脒盐酸盐, 吡唑-1-氨基亚胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C4H6N4 · HCl
化学文摘社编号:
分子量:
146.58
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
429-520-1
Beilstein/REAXYS Number:
5448758
MDL number:
Assay:
99%
Form:
powder
Quality Level
InChI key
RBZRMBCLZMEYEH-UHFFFAOYSA-N
InChI
1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H
SMILES string
Cl[H].NC(=N)n1cccn1
assay
99%
form
powder
mp
167-170 °C (lit.)
functional group
amine
General description
1H-吡唑-1-甲酰脒盐酸盐为吡唑衍生物，为杂环化合物。在药物合成研究中应用广泛。吡唑环构成了各种非甾体抗炎药 (NSAIDs) 和抗高血压药物的主要核心。
Application
1H-吡唑-1-甲脒盐酸盐可用于以下研究：
- 胍基中空纤维膜的制备。
- 胺类的鸟苷酸化和肽合成。
- 双胍胆固醇衍生物的合成。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Hironori Izawa et al.
Biomolecules, 9(7) (2019-07-10)
In order to synthesize a promising material for developing a novel peptide/protein delivery system, guanidinylation of chitooligosaccharides with 1-amidinopyrazole hydrochloride was investigated herein. The production of guanidinylated chitooligosaccharides was demonstrated by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and elemental
Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells.
J P Vigneron et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(18), 9682-9686 (1996-09-03)
Two cationic lipids, bis-guanidinium-spermidine-cholesterol (BGSC) and bis-guanidinium-trencholesterol (BGTC)-cholesterol derivatives bearing two guanidinium groups-have been synthesized and tested as artificial vectors for gene transfer. They combine the membrane compatible features of the cholesterol subunit and the favorable structural and high pKa
1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis.
Bernatowicz MS, et al.
The Journal of Organic Chemistry, 57(8), 2497-2502 (1992)
Xiao Zhang et al.
ACS applied materials & interfaces, 12(14), 16088-16096 (2020-03-17)
Supramolecular hydrogels have great potential as biomaterials for tissue engineering applications or vehicles for delivering therapeutic agents. Herein, a self-healing and pro-osteogenic hydrogel system is developed based on the self-assembly of laponite nanosheets and guanidinylated chitosan, where laponite works as
Anna Yu Spivak et al.
Steroids, 154, 108530-108530 (2019-11-05)
A series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their antimicrobial activity against the growth of four bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA))
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