407771
4-乙氧基-1,1,1-三氟-3-丁烯-2-酮
contains 0.5% BHT as stabilizer, technical grade
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关于此项目
线性分子式:
C2H5OCH=CHCOCF3
化学文摘社编号:
分子量:
168.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
liquid
InChI
1S/C6H7F3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3/b4-3+
SMILES string
CCO\C=C\C(=O)C(F)(F)F
InChI key
YKYIFUROKBDHCY-ONEGZZNKSA-N
grade
technical grade
form
liquid
contains
0.5% BHT as stabilizer
refractive index
n20/D 1.406 (lit.)
bp
51-53 °C/12 mmHg (lit.)
density
1.18 g/mL at 25 °C (lit.)
functional group
ether, fluoro, ketone
storage temp.
2-8°C
General description
4-乙氧基-1,1,1-三氟-3-丁烯-2-酮可与苯基溴化镁反应生成乙氧基取代产物，并同时与有机锌化合物反应生成由羰基1,2-加成反应生成的产物。4-乙氧基-1,1,1-三氟-3-丁烯-2-酮在与亚磷酸三乙酯一起加热时可生成[4 + 2]环加成产物2,2,2-三乙氧基2,3-二氢-3-乙氧基- 5-三氟甲基-1,2λ5-氧杂磷腈，其水解后可生成2-氧代-2-羟基-2,3-二氢-3-羟基5-三氟甲基-1,2λ5-氧杂磷烯。它可与氨基反应生成N-保护的氨基酸用于肽合成。
Application
4-乙氧基-1,1,1-三氟-3-丁烯-2-酮可用于合成4-二烷基氨基-1,1,1-三氟丁-3-烯-2-酮。它可用于合成带有CF3基团的β-烷基-或二烷基氨基取代的烯酮。
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Carc. 2 - Flam. Liq. 3
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
125.6 °F - closed cup
flash_point_c
52 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
4-Ethoxy-1, 1, 1-trifluoro-3-buten-2one as a new protecting reagent in peptide synthesis.
Gorbunova MG, et al.
Synthesis, 3, 207-209 (1991)
Synthesis of Trifluoromethylpyrroles and Related Heterocycles from 4-Ethyloxy-1, 1, 1-trifluorobut-3-ene-2-one.
Andrew RJ and Mellor JM.
Tetrahedron, 56(37), 7267-7272 (2000)
The interaction of 4-ethoxy-1, 1, 1-trifluoro-3-buten-2-one with C-nucleophiles-organo-magnesium and-zinc compounds
Gorbunova MG, et al.
Journal of Fluorine Chemistry, 65(1), 25-28 (1993)
The interaction of 4-ethoxy-1, 1, 1-trifluoro-3-buten-2-one with triethyl phosphite.
Gerus II, et al.
Journal of Fluorine Chemistry, 90(1), 1-3 (1998)
Preparation of α, β-unsaturated ketones bearing a trifluoromethyl group and their application in organic synthesis.
Nenajdenko VG, et al.
Molecules (Basel), 2(12), 186-232 (1997)
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