410403
2-肼基-4-三氟甲基嘧啶
99%
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关于此项目
经验公式（希尔记法）:
C5H5F3N4
化学文摘社编号:
分子量:
178.12
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
Assay:
99%
产品名称
2-肼基-4-三氟甲基嘧啶, 99%
InChI
1S/C5H5F3N4/c6-5(7,8)3-1-2-10-4(11-3)12-9/h1-2H,9H2,(H,10,11,12)
SMILES string
NNc1nccc(n1)C(F)(F)F
InChI key
XQCAINVUBSAUBJ-UHFFFAOYSA-N
assay
99%
mp
99-101 °C (lit.)
Application
2-Hydrazino-4-(trifluoromethyl)pyrimidine may be used in the following studies:
- As derivatization reagent for the simultaneous determination of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples by liquid chromatography-electrospray ionization-tandem mass spectrometry.
- Synthesis of organohydrazide chelate complexes of rhenium and technetium, having a metal-nitrogen-nitrogen linkage.
- Preparation of 1-(4-methoxyphenyl)ethanone [(4-trifluoromethyl)pyrimidine-2-yl]hydrazone (NAS-75).
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
The synthesis and characterization of technetium and rhenium hydrazinopyrimidine chelate complexes.
Hirsch-Kuchma M, et al.
J. Chem. Soc., Dalton Trans., 18, 3185-3188 (1997)
Jukkarin Srivilai et al.
Steroids, 116, 67-75 (2016-10-31)
Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. The method for screening for S5αR inhibition is
Yan Weng et al.
Analytical biochemistry, 402(2), 121-128 (2010-04-07)
A novel method was established for simultaneous quantitation of testosterone (T) and dihydrotestosterone (DHT) in murine tissue and serum samples. Endogenous T and DHT, together with the internal standards 17alpha-methyl-T and 17alpha-methyl-DHT, were extracted from tissues and then derivatized by
Shailendra Kumar Sharma et al.
The Journal of biological chemistry, 278(46), 45661-45671 (2003-08-22)
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new antimalarials. In this context, the fatty acid biosynthesis (FAS) pathway of the malarial parasite has recently received a lot of attention. Due to differences in the
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