412422
PAMAM 树枝状聚合物，乙二胺核，3.0 代 溶液
20 wt. % in methanol
别名:
Starburst PAMAM-G 3
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关于此项目
线性分子式:
[NH2(CH2)2NH2]:(G=3);dendri PAMAM(NH2)32
化学文摘社编号:
分子量:
6908.84
UNSPSC Code:
12162002
NACRES:
NA.23
MDL number:
产品名称
PAMAM 树枝状聚合物，乙二胺核，3.0 代 溶液, 20 wt. % in methanol
description
amino surface groups
form
liquid
mol wt
generation 3.0
feature
core type ethylenediamine core (2-carbon core)
concentration
20 wt. % in methanol
no. Surface Groups
32
refractive index
n20/D 1.367
bp
64.7 °C
density
0.863 g/mL at 25 °C
storage temp.
2-8°C
Quality Level
Application
PAMAM树状聚合物可作为核酸递送的转染剂使用。例如，它可用于靶向肿瘤坏死因子(TNF)的siRNA的肺部给药。
General description
PAMAM树状聚合物是一种具有大量末端基团的对称聚合物，由于其生物相容性和亲和性，可以轻易地与生物分子结合。这些树枝状聚合物具有多价表面，其中包含包膜和与树枝相附的核内各种活性位点。它们是高度分支的纳米级聚合物，广泛用于在生物医学领域的靶向给药。
Legal Information
由 Dendritech® 公司生产。
Dendritech is a registered trademark of Dendritech, Inc.
Physical form
含有 32 个表面伯氨基
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
法规信息
危险化学品
此项目有
Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-? siRNA with PAMAM dendrimers in a murine model
Adam Bohr, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 156, 114-120 (2020)
Polyamidoamine dendrimers: Favorable polymeric nanomaterials for lipase activation
Amal A.M. Elgharbawy, et al.
Materials Today Communications, 25, 101492-101492 (2020)
Ajay Vikram Singh et al.
ACS applied materials & interfaces, 13(1), 1943-1955 (2020-12-30)
In an in vitro nanotoxicity system, cell-nanoparticle (NP) interaction leads to the surface adsorption, uptake, and changes into nuclei/cell phenotype and chemistry, as an indicator of oxidative stress, genotoxicity, and carcinogenicity. Different types of nanomaterials and their chemical composition or
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Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.
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