412449
PAMAM 树枝状聚合物，乙二胺核，4.0 代 溶液
10 wt. % in methanol
别名:
Starburst树枝状聚合物第4代
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关于此项目
线性分子式:
[NH2(CH2)2NH2]:(G=4);dendri PAMAM(NH2)64
化学文摘社编号:
分子量:
14214.17
MDL编号:
UNSPSC代码:
12162002
NACRES:
NA.23
描述
amino surface groups
质量水平
表单
solution
分子量
generation 4.0
特点
core type ethylenediamine core (2-carbon core)
浓度
10 wt. % in methanol
表面基团编号
64
折射率
n20/D 1.348
沸点
64.7 °C
密度
0.813 g/mL at 25 °C
储存温度
2-8°C
一般描述
PAMAM树枝状聚合物，乙二胺核，4代溶液是酰胺—胺聚合物，属于树枝状聚合物。可通过两步法的界面交互反应形成围绕乙二胺中心核的代而进行制备。它含有通过正规“支化再支化”模式组装的氮和酰胺官能团。它主要用作高容量螯合剂。
应用
PAMAM树枝状聚合物，乙二胺核，4代溶液可作为引起DNA分子构象变化的压缩剂。它可结合纤维素底物，构建可用于免疫检测的生物功能表面。它可用于MRI对比剂和二氧化硅纳米球的冷凝制备。
外形
含有 64 个表面伯氨基
法律信息
由 Dendritech® 公司制造
Dendritech is a registered trademark of Dendritech, Inc.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
51.8 °F - closed cup
闪点(°C)
11 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
此项目有
Felipe Vidal et al.
Molecular pharmaceutics, 13(10), 3395-3403 (2016-08-25)
Polyamidoamine (PAMAM) dendrimers are hyperbranched macromolecules which have been described as one of the most promising drug nanocarrier systems. A key process to understand is their cellular internalization mechanism because of its direct influence on their intracellular distribution, association with
DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation
Ainalem M, et al.
PLoS ONE, 9(3), e92692-e92692 (2014)
Rolando Alberto Rodríguez-Fonseca et al.
Colloids and surfaces. B, Biointerfaces, 177, 77-93 (2019-02-04)
Peptide epitopes have been widely used to develop synthetic vaccines and immunotherapies. However, peptide epitopes may exhibit poor absorption or immunogenicity due to their low molecular weights. Conversely, fourth-generation polyamidoamine (G4-PAMAM) dendrimers are nonimmunogenic and relatively nontoxic synthetic nanoparticles that
Kobayashi, H., et al.
Magn. Reson. in Med., 50, 758-758 (2003)
Dendritic chelating agents. 1. Cu (II) binding to ethylene diamine core poly (amidoamine) dendrimers in aqueous solutions
Diallo MS, et al.
Langmuir, 20(7), 2640-2651 (2004)
商品
Replace volatile organic solvents with water due to environmental concerns, overcoming challenges in solubility.
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