412562
(S)-(-)-二氨基丙烷 二盐酸盐
99%
别名:
(S)-(-)-丙二胺 二盐酸盐, (S)-1,2-丙二胺 二盐酸盐
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关于此项目
线性分子式:
CH3CH(NH2)CH2NH2·2HCl
化学文摘社编号:
分子量:
147.05
Beilstein:
5740936
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.22
方案
99%
旋光性
[α]22/D −4°, c = 20 in H2O
mp
227-229 °C (lit.)
官能团
amine
SMILES字符串
Cl.Cl.C[C@H](N)CN
InChI
1S/C3H10N2.2ClH/c1-3(5)2-4;;/h3H,2,4-5H2,1H3;2*1H/t3-;;/m0../s1
InChI key
AEIAMRMQKCPGJR-QTNFYWBSSA-N
应用
(S)-(-)-1,2-Diaminopropane dihydrochloride may be used in the preparation of following chiral imidazoline derivatives, which show moderate α-adrenergic blocking activity:
- (S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride
- (S)-(-)-2-benzyl-4-methylimidazoline picrate
- (S )-(-)-2-[(2,6-dichlorophenyl)imino]-4-methylimidazolidine hydrochloride
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Optically active derivatives of imidazolines: a-Adrenergic blocking properties.
Hsu FL, et al.
Journal of Medicinal Chemistry, 23(11), 1232-1235 (1980)
Stereochemical studies of adrenergic drugs. Optically active derivatives of imidazolines.
Miller DD, et al.
Journal of Medicinal Chemistry, 19(12), 1382-1384 (1976)
M A Medina et al.
The Biochemical journal, 280 ( Pt 3), 825-827 (1991-12-15)
1. L-Ornithine transport by plasma-membrane vesicles isolated from Ehrlich cells is Na(+)-independent and shows a saturable and a diffusional component. 2. Putrescine, histamine, 5-hydroxytryptamine and 2,3-diaminopropane at 55 microM concentration significantly inhibit 0.5 mM-L-ornithine transport at least for the first
G Auling et al.
Applied and environmental microbiology, 57(12), 3585-3592 (1991-12-01)
Polyphosphate-accumulating gram-negative bacteria were isolated from different anaerobic-aerobic activated sludge systems with diverse processes for enhanced biological phosphorus (P) elimination. Of 22 isolates, 10 were allocated to the genus Acinetobacter by using multiple-test systems and soluble protein and polyamine patterns.
Lorin A Thompson et al.
Bioorganic & medicinal chemistry letters, 21(22), 6909-6915 (2011-10-07)
The synthesis, evaluation, and structure-activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in
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