assay
98%
mp
165-167 °C (lit.)
SMILES string
O=C1CCc2ccccc2N1
InChI
1S/C9H9NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-4H,5-6H2,(H,10,11)
InChI key
TZOYXRMEFDYWDQ-UHFFFAOYSA-N
General description
合成了一系列具有 sigma-1 受体（σ1R）拮抗剂活性的 3,4-二氢-2(1H)-喹啉酮衍生物。使用N-(1′-烷氧基)环丙基-2-卤代苯胺作为起始试剂合成了 3,4-二氢-2((1)H)-喹啉酮。在钯催化剂的存在下环丙烷环的扩环反应是合成的主要步骤。通过在固相上重排 β-内酰胺中间体合成了 3,4-二氢-2(1H)-喹啉酮的文库
Application
在富集培养实验中，可以将 3,4-二氢-2（1H）-喹啉酮用作在假单胞菌培养基中的培养基补充剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Selective removal of nitrogen from quinoline and petroleum by Pseudomonas ayucida IGTN9m.
Kilbane JJ, et al.
Applied and Environmental Microbiology, 66(2), 688-693 (2000)
So Youn Park et al.
Behavioural brain research, 365, 133-140 (2019-03-10)
Cerebrovascular dysfunction is associated with cognitive impairment in vascular dementia patients. This study aimed to explore augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in vascular dementia model. Male C57BL/6 mice were subjected to BCAS, and
Synthesis of 4-amino-3, 4-dihydro-2 (1H)-quinolinones via β-lactam intermediates on the solid-phase.
Pei Y, et al.
Tetrahedron Letters, 38(19), 3349-3352 (1997)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 415936-1G | 04061826258224 |
| 415936-10G | 04061833432037 |