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419656

苄哒唑

Name: 苄哒唑
Brand: ALDRICH

97%

别名:

2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide, Benzonidazol, N-Benzyl-2-nitroimidazol-1-yl-acetamide

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₂N₄O₃

化学文摘社编号:

22994-85-0

分子量:

260.25

NACRES:

NA.22

PubChem Substance ID:

24866267

UNSPSC Code:

12352100

MDL number:

MFCD00243089

Assay:

97%

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属性

Quality Level

100

assay

97%

mp

189-192 °C (lit.)

solubility

methanol: soluble 50 mg/mL, clear, colorless to yellow

functional group

amide, nitro, phenyl

SMILES string

[O-][N+](=O)c1nccn1CC(=O)NCc2ccccc2

InChI

1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)

InChI key

CULUWZNBISUWAS-UHFFFAOYSA-N

说明

General description

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..

Application

N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) may be used as reference drug for the extraction of guaianolide from the aerial parts of Tanacetum parthenium and to evaluate its in vitro antiprotozoal activity.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Antiparasitic Effect of Vitamin B12 on Trypanosoma cruzi.

Alejandra B Ciccarelli et al.

Antimicrobial agents and chemotherapy, 56(10), 5315-5320 (2012-08-08)

A nutritional characteristic of trypanosomatid protozoa is that they need a heme compound as a growth factor. Because of the cytotoxic activity of heme and its structural similarity to cobalamins, we have investigated the in vitro and in vivo effect

Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.

Israel Molina et al.

The New England journal of medicine, 370(20), 1899-1908 (2014-05-16)

Current therapeutic options for Chagas' disease are limited to benznidazole and nifurtimox, which have been associated with low cure rates in the chronic stage of the disease and which have considerable toxicity. Posaconazole has shown trypanocidal activity in murine models.

Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study.

D E Perez-Mazliah et al.

The Journal of antimicrobial chemotherapy, 68(2), 424-437 (2012-10-30)

Even though the use of combined drugs has been proved to be effective in other chronic infections, assessment of combined treatment of antiparasitic drugs in human Chagas' disease has not been performed. Herein, a pilot study was conducted to evaluate

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全球贸易项目编号

货号	GTIN
419656-1G	04061832092461