421731
(S)-(+)-2-联苄基氨基-3-苯基-1-丙醇
99%
别名:
N,N-二苄基-L-苯基丙氨醇
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关于此项目
线性分子式:
C6H5CH2CH[N(CH2C6H5)2]CH2OH
化学文摘社编号:
分子量:
331.45
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
Assay:
99%
Form:
solid
Quality Segment
assay
99%
form
solid
optical activity
[α]20/D +8.0°, c = 4 in methanol
mp
72-74 °C (lit.)
functional group
amine, hydroxyl, phenyl
SMILES string
OC[C@H](Cc1ccccc1)N(Cc2ccccc2)Cc3ccccc3
InChI
1S/C23H25NO/c25-19-23(16-20-10-4-1-5-11-20)24(17-21-12-6-2-7-13-21)18-22-14-8-3-9-15-22/h1-15,23,25H,16-19H2/t23-/m0/s1
InChI key
ZXNVOFMPUPOZDF-QHCPKHFHSA-N
Application
用于合成 HIV 蛋白酶抑制剂的结构单元。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
相关内容
D Scholz et al.
Journal of medicinal chemistry, 37(19), 3079-3089 (1994-09-16)
A convenient procedure for the synthesis of 2-heterosubstituted statine derivatives as novel building blocks in HIV-protease inhibitors has been developed. The synthesis starts with protected L-phenylalaninols, which were converted to gamma-amino alpha, beta-unsaturated esters in a one-pot procedure. A highly
Pierre L. Beaulieu et al.
The Journal of organic chemistry, 61(11), 3635-3645 (1996-05-31)
Enantiomerically pure N,N-dibenzyl-alpha-amino aldehydes reacted with (chloromethyl)lithium, generated in situ from bromochloromethane and lithium metal, to give predominantly erythro aminoalkyl epoxides. Treatment of the crude epoxides with aqueous hydrochloric acid gave crystalline (2S,3S)-N,N-dibenzylamino chlorohydrin hydrochlorides in 32-56% overall yield and
Liu, C. et al.
Organic Process Research & Development, 1, 45-45 (1997)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 421731-5G | 04061832728254 |