产品名称
2-氯-N-(羟甲基)乙酰胺, 98%
InChI key
TXNSZCSYBXHETP-UHFFFAOYSA-N
InChI
1S/C3H6ClNO2/c4-1-3(7)5-2-6/h6H,1-2H2,(H,5,7)
SMILES string
OCNC(=O)CCl
assay
98%
mp
100-105 °C (lit.)
Quality Level
Application
2-氯-N-（羟甲基）乙酰胺（N-羟甲基氯乙酰胺）可以用作合成 1-（氨基甲基）-2-甲氧基萘盐酸盐的试剂，也可用作 N,N-二烷基苯胺的氨甲基化试剂（Tscherniac-Einhorn 反应）。
General description
2-氯-N-（羟甲基）乙酰胺（N-羟甲基氯乙酰胺) 是氯乙酰胺的 N-羟甲基衍生物。已报道的合成方法之一是通过2-氯乙酰胺和甲醛的反应。据报道它是一种甲醛释放剂和甲醛接触过敏的不常见敏化剂。研究人员已经研究过短期和长期接触2-氯-N-（羟甲基）乙酰胺（作为甲醛供体/释放剂）对淋巴结反应的影响。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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This is one of series of review articles on formaldehyde and formaldehyde-releasers (others: formaldehyde in cosmetics, in clothes and in metalworking fluids and miscellaneous). Thirty-five chemicals were identified as being formaldehyde-releasers. Although a further seven are listed in the literature
J Ashby et al.
Mutation research, 156(1-2), 19-32 (1985-04-01)
The industrial biocide chloracetamide-N-metholol (CAM) has been shown to be non-mutagenic to 6 strains of Salmonella using both the plate-incorporation and a pre-incubation test protocol. Its biocidal activity is unlikely to have influenced these results since Kathon 886, a more
Allergic contact dermatitis from the preservative N-methylol-chloracetamide.
S Agren et al.
Contact dermatitis, 6(4), 302-303 (1980-06-01)
Anton de Groot et al.
Contact dermatitis, 63(3), 129-139 (2010-06-25)
We have reviewed formaldehyde-releasers used in metalworking fluids (MWFs) in this and a previous part of a two-part article. These biocides do not appear to be frequent or important sensitizers. Even in highly selected patient groups of metalworkers, mean prevalence
Occupational contact dermatitis to N-methylol-chloracetamide.
M Farli et al.
Contact dermatitis, 17(3), 182-184 (1987-09-01)
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