42358
双十八烷基胺
≥99.0% (NT)
别名:
DODA, 二硬脂酸胺
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线性分子式:
[CH3(CH2)17]2NH
化学文摘社编号:
分子量:
521.99
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
204-020-2
Beilstein/REAXYS Number:
1801688
MDL number:
Assay:
≥99.0% (NT)
产品名称
双十八烷基胺, ≥99.0% (NT)
InChI key
HKUFIYBZNQSHQS-UHFFFAOYSA-N
InChI
1S/C36H75N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h37H,3-36H2,1-2H3
SMILES string
CCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCC
assay
≥99.0% (NT)
mp
71-73 °C
solubility
water: soluble(lit.)
functional group
amine
Quality Level
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Application
二十八烷基胺（DODA）是用于以下合成的合适试剂：
- 二十八烷基胺-BCN（双环[6.1.0]壬炔）缀合物。
- 双乙基去甲精胺（BSP）的脂质衍生物。
- 功能性VP（N-乙烯基吡咯烷酮）聚合物。
- 作为与二琥珀酰亚胺基 4,4'-偶氮双（4-氰基戊酸酯）反应合成 4,4'-偶氮双（4-氰基- N,N -双十八烷基）戊酰胺 (DODA-501) 的反应物。
- 作为合成双十八烷基七肽的试剂。
- 作为金纳米粒子 (AuNPs) 在非极性溶剂中的相转移和稳定剂。
General description
二十八烷基胺（DODA）是一种仲胺，是一种脂肪胺衍生物。 已经评估了其生物降解潜力。观察发现，在水性介质中，DODA自身组织成板状结构。分析了其部分电荷分布与其构象的关系。 已确定二十八烷基胺Langmuir单层的相图，研究表明其在pH 3.9以上不会形成单层。DODA已用于形成脂质体、阳离子脂质或脂质螯合剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Emmanuelle Roux et al.
Journal of pharmaceutical sciences, 91(8), 1795-1802 (2002-07-13)
The aim of this study was to characterize a pH-sensitive liposome formulation bearing a terminally alkylated N-isopropylacrylamide (NIPAM) copolymer with regard to its pH responsiveness, surface properties, and pharmacokinetics. The interacting forces between two lipid bilayers bearing the anchored NIPAM
Samuel F Brockington et al.
The New phytologist, 207(4), 1170-1180 (2015-05-15)
Betalain pigments are unique to the Caryophyllales and structurally and biosynthetically distinct from anthocyanins. Two key enzymes within the betalain synthesis pathway have been identified: 4,5-dioxygenase (DODA) that catalyzes the formation of betalamic acid and CYP76AD1, a cytochrome P450 gene
The dioctadecylamine monolayer: Textures, phase transitions, and dendritic growth.
Flores A, et al.
J. Chem. Phys. , 119(11), 5644-5653 (2003)
K Tagawa et al.
Bioconjugate chemistry, 10(3), 354-360 (1999-05-29)
Novel amphiphiles which carry many mannose residues as side chains were prepared by telomerization of N-methacryloylaminopropyl D-mannopyranoside (alpha:beta = 20:1), N-methacryloylaminohexyl D-mannopyranoside (alpha:beta = 20:1), or 3-(2-methacryloylaminoethylthio)propyl D-mannopyranoside (alpha:beta = 4:1) using a lipophilic radical initiator. The mannose-carrying amphiphiles incorporated
Yanmei Dong et al.
Molecular pharmaceutics, 9(6), 1654-1664 (2012-05-02)
Progress in the development of nonviral gene delivery vectors continues to be hampered by low transfection activity and toxicity. Here we proposed to develop a lipid prodrug based on a polyamine analogue bisethylnorspermine (BSP) that can function dually as gene
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