426016
4,4,4-三氟-1-（2-呋喃基）-1,3-丁二酮
99%
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关于此项目
经验公式（希尔记法）:
C8H5F3O3
化学文摘社编号:
分子量:
206.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
206-315-1
MDL number:
产品名称
4,4,4-三氟-1-（2-呋喃基）-1,3-丁二酮, 99%
InChI key
OWLPCALGCHDBCN-UHFFFAOYSA-N
InChI
1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
SMILES string
FC(F)(F)C(=O)CC(=O)c1ccco1
assay
99%
form
liquid
refractive index
n20/D 1.528 (lit.)
bp
203 °C (lit.)
mp
19-21 °C (lit.)
density
1.391 g/mL at 25 °C (lit.)
functional group
fluoro
ketone
storage temp.
2-8°C
Quality Level
Application
4,4,4-三氟-1-(2-呋喃基)-1,3-丁二酮(tfa)可用于以下研究：
- 在[Eu(tfa)3]2bpm络合物(bpm=2,2′-二嘧啶)的合成中作为封顶配体。
- 在[13CD2]苄胺的多步合成中用作试剂。
- 作为合成3-三氟甲基-2-芳基羰基喹啉1,4-di-N-氧化物衍生物的试剂，与相应的苯并呋咱氧化物反应。
- 在全氟烷基取代唑的有效合成中。
- 2-芳基羰基-3-三氟甲基喹啉1,4-di-N-氧化物衍生物的合成。
General description
4,4,4-三氟-1-(2-呋喃基)-1,3-丁二酮（呋喃基三氟丙酮，FTFA）为β-二酮。对体外培养的肿瘤细胞和正常细胞进行了细胞毒活性评价。研究表明，4,4,4-三氟-1-(2-呋喃基)-1,3-丁二酮能部分抑制ETP（电子传递粒子，从牛肉心脏线粒体分离）中亚铁氰化物的氧化。 研究了它与N,N,N′,N′-四甲基烷基二胺的反应形成离子加合物。本文报道了烯醇和酮两种形式的超疏水脂肪酸的构象分析。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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The role of gamma-glutamyltranspeptidase (GGT) in transferring glutamate from endogenous glutathione (GSH) to the benzylamine moiety of a compound, such as 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423), is described. Studies were performed with structurally related analogs of DPC 423 to demonstrate that this
Conformation, structure, intramolecular hydrogen bonding, and vibrational assignment of 4,4, 4-trifluoro-1-(2-furyl)-1,3-butanedione.
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Journal of Molecular Structure, 8882(1), 153-167 (2008)
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