429856
2-氨基-6-氟苯腈
99%
别名:
2-氰基-3-氟苯胺
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关于此项目
线性分子式:
H2NC6H3(F)CN
化学文摘社编号:
分子量:
136.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
99%
assay
99%
mp
125-128 °C (lit.)
functional group
fluoro, nitrile
storage temp.
2-8°C
SMILES string
Nc1cccc(F)c1C#N
InChI
1S/C7H5FN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H2
InChI key
IQUNZGOZUJITBJ-UHFFFAOYSA-N
General description
2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.
Application
一种药物化学中间体，用于制备他克林衍生物 以及抗叶酸剂和抗菌的喹唑啉衍生物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
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本期生物档案回顾了我们的一些最新和最具创新性的技术及其在癌症研究中的具体应用。在准备本期生物档案时，有人指出癌症极为复杂，要确定一个与其他主题完全无关的主题极为困难。。
N V Harris et al.
Journal of medicinal chemistry, 33(1), 434-444 (1990-01-01)
A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources. The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is
Synthesis of 5-and 7-fluoroquinazolin-4 (1H)-ones.
Layeva AA, et al.
Russian Chemical Bulletin, 56(9), 1821-1827 (2007)
European Journal of Medicinal Chemistry, 29, 205-205 (1994)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 429856-1G | 04061825770987 |
| 429856-10G | 04061832100036 |