429856
2-氨基-6-氟苯腈
99%
别名:
2-氰基-3-氟苯胺
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关于此项目
线性分子式:
H2NC6H3(F)CN
化学文摘社编号:
分子量:
136.13
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
2-氨基-6-氟苯腈, 99%
InChI
1S/C7H5FN2/c8-6-2-1-3-7(10)5(6)4-9/h1-3H,10H2
SMILES string
Nc1cccc(F)c1C#N
InChI key
IQUNZGOZUJITBJ-UHFFFAOYSA-N
assay
99%
mp
125-128 °C (lit.)
functional group
fluoro
nitrile
storage temp.
2-8°C
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Application
一种药物化学中间体，用于制备他克林衍生物 以及抗叶酸剂和抗菌的喹唑啉衍生物。
General description
2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Synthesis of 5-and 7-fluoroquinazolin-4 (1H)-ones.
Layeva AA, et al.
Russian Chemical Bulletin, 56(9), 1821-1827 (2007)
N V Harris et al.
Journal of medicinal chemistry, 33(1), 434-444 (1990-01-01)
A series of 5-substituted 2,4-diaminoquinazolines (3) has been synthesized and evaluated as inhibitors of the enzyme dihydrofolate reductase (DHFR) from both bacterial and mammalian sources. The best compounds (e.g. 53) show good activity against Escherichia coli DHFR, but there is
European Journal of Medicinal Chemistry, 29, 205-205 (1994)
Julien Defaux et al.
Bioorganic & medicinal chemistry, 19(5), 1702-1707 (2011-02-15)
A series of 19 huprines has been evaluated for their activity against cultured bloodstream forms of Trypanosoma brucei and Plasmodium falciparum. Moreover, cytotoxicity against rat myoblast L6 cells was assessed for selected huprines. All the tested huprines are moderately potent
N-(aminophenyl)oxamic acids and esters as potent, orally active antiallergy agents.
D H Klaubert et al.
Journal of medicinal chemistry, 24(6), 742-748 (1981-06-01)
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