439320
4-三氟甲基苯基硼酸
≥95.0%
别名:
α,α,α-三氟-p-甲苯基硼酸, 4-(三氟甲基)苯硼酸
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关于此项目
线性分子式:
CF3C6H4B(OH)2
化学文摘社编号:
分子量:
189.93
NACRES:
NA.22
UNSPSC Code:
12352103
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3544189
Quality Level
assay
≥95.0%
mp
245-250 °C (lit.)
functional group
fluoro
SMILES string
OB(O)c1ccc(cc1)C(F)(F)F
InChI
1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
InChI key
ALMFIOZYDASRRC-UHFFFAOYSA-N
Application
4-三氟甲基苯基硼酸可用作以下物质的反应物：
它也可作为反应物合成：
- 位点选择Suzuki-Miyaura交叉偶联反应
- 钯催化的直接芳基化反应
- 串联型Pd(II) 催化的氧化Heck反应和分子内C-H酰胺化序列
- 钌催化的直接芳基化
- 无配体铜催化的偶联反应
- 胺化和结合物加成反应
- 通过Suzuki-Miyaura和Sonogashira交叉偶联反应进行区域选择性芳基化和炔基化
- 铑催化不对称1,4-加成反应
- 铜催化的硝化反应
- 区域选择性Suzuki-Miyaura偶联和串联钯催化的分子内氨基羰基化和环化
- 钯催化的烯丙醇的烯丙基化反应
- 以铜交换氟磷灰石为催化剂进行咪唑和胺的N-芳基化反应
它也可作为反应物合成：
- 可打印电子设备用噻唑衍生物
- 三联苯苯并咪唑类微管蛋白聚合抑制剂
- 芳基酮（通过与酰氯发生交叉偶联反应）
Other Notes
含有不定量的酸酐。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Viktor O Iaroshenko et al.
Organic & biomolecular chemistry, 10(15), 2955-2959 (2012-03-10)
A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported
Palladium(0)-catalyzed direct cross-coupling reaction of allyl alcohols with aryl- and vinyl-boronic acids
Hirokazu Tsukamoto, et al.
Chemical Communications (Cambridge, England), 1200-1201 (2004)
M Lakshmi Kantam et al.
The Journal of organic chemistry, 71(25), 9522-9524 (2006-12-02)
N-Arylation of imidazoles and amines with arylboronic acids was accomplished with copper-exchanged fluorapatite (CuFAP) in methanol at room temperature. The products N-arylimidazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids were converted to the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 439320-1G | 04061832246031 |
| 439320-5G | 04061832246048 |