439606
二烯丙基 N,N-二异丙基亚磷酰胺
别名:
N，N-双（1-甲基乙基）磷酰胺酸二-2-丙烯基酯, 二烯丙氧基（二异丙基氨基）膦
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关于此项目
线性分子式:
[(CH3)2CH]2NP(OCH2CH=CH2)2
化学文摘社编号:
分子量:
245.30
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4383514
Form:
liquid
InChI
1S/C12H24NO2P/c1-7-9-14-16(15-10-8-2)13(11(3)4)12(5)6/h7-8,11-12H,1-2,9-10H2,3-6H3
SMILES string
CC(C)N(C(C)C)P(OCC=C)OCC=C
InChI key
QBLCHHSGJTUNSJ-UHFFFAOYSA-N
form
liquid
Quality Level
bp
130 °C (lit.)
density
0.928 g/mL at 25 °C (lit.)
functional group
amine
storage temp.
2-8°C
Application
参与药理活性分子合成的前体包括：
作为反应物，参与以下反应：
- 选择性口服活性S1P1激动剂
- 具有抗真菌活性的三唑CS-758的水溶性前药
- 作为抗肿瘤剂的福司曲星类似物
作为反应物，参与以下反应：
- 乙醇磷酸化
- 脱烯丙基化合成核苷亚磷酰胺
- 磷酸化和立体选择性Pudovik重排
在以下研究中，二烯丙基N，N-二异丙基亚磷酰胺可用作磷酸化试剂：
- 肽底物制备。
- 具有磷酸化CH2OH位点的罗丹明染料的制备。
- 3-[4-（双烯丙氧基-磷酰氧基）-2（R）-羟基-3，3-二甲基-丁酰氨基]-硫代丙酸-S-丙酯的合成。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
89.6 °F - closed cup
flash_point_c
32 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
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