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Merck
CN

440744

Sigma-Aldrich

聚已酸内酯

greener alternative

average Mn 80,000

别名:

2-氧杂环庚烷酮均聚物, 6-己内酯聚合物

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关于此项目

线性分子式:
(C6H10O2)n
UNSPSC代码:
12162002
NACRES:
NA.23

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表单

pellets (~3 mm)

质量水平

200

分子量

average Mn 80,000

环保替代产品特性

Design for Energy Efficiency
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

杂质

<0.5% water

mp

60 °C (lit.)

密度

1.145 g/mL at 25 °C

Mw/Mn

<2

应用

3D bioprinting
advanced drug delivery

环保替代产品分类

Enabling

SMILES字符串

C1CCC(=O)OCC1 (Canonical-SMILES)

InChI

1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2

InChI key

PAPBSGBWRJIAAV-UHFFFAOYSA-N

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相关类别

一般描述

我们竭诚为您带来属于我们绿色替代产品四大类别之一的绿色替代产品。本品属于赋能型产品。作为高性能生物基聚合物，十分适于开发高效、低成本和环境友好的再生能源方案。点击此处以获取更多信息。
聚己内酯(PCL)是一种半晶态疏水性可生物降解聚酯，具有成本低、韧性好、生物相容性好等优点，在医药领域有着广泛的应用。PCL具有一些独特的性质，如:
  • 在生理条件下，它的降解速度比其他生物可降解聚酯慢，这一特性可以在一段时间内用于靶组织药物的可控释放。
  • 由于其疏水性，其表面润湿性较差，与生物液体的相互作用较差，导致较差的细胞黏附和增殖能力，因此与其他合成/天然聚合物混合使用。

应用

  • 负载抗生素的PCL可用于治疗呼吸道感染，如肺结核。
  • 已有研究关于人骨髓间充质细胞(hBMSCs)对不同比例的壳聚糖/聚己内酯(PCL)共混物的表型反应。
  • PCL/生物医用陶瓷材料已被研究用于可能的骨组织再生。
  • PCL/分级胰岛素/beta-5甘油磷酸酯浓度通过脂肪来源的基质细胞分化对骨软骨组织形成的作用。
  • 其它通用用途包括:压出助剂、模具润滑剂、脱模剂、颜料和填料分散助剂以及聚氨酯和嵌段聚酯中的聚酯段。

特点和优势

可生物降解聚合物
无毒、土壤中可生物降解、混合性优异、与许多聚合物具有机械相容性以及对许多基质具有良好粘性。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000494209
0000494211
0000494211
0000494209
0000490118

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Cevat Erisken et al.
Tissue engineering. Part A, 17(9-10), 1239-1252 (2010-12-30)
The ability to fabricate tissue engineering scaffolds containing systematic gradients in the distributions of stimulators provides additional means for the mimicking of the important gradients observed in native tissues. Here the concentration distributions of two bioactive agents were varied concomitantly
Hung-Jen Shao et al.
Journal of biomedical materials research. Part A, 100(12), 3344-3352 (2012-06-27)
The phenotypic responses of human bone marrow mesenchymal cells (hBMSCs) on different ratio of chitosan/polycaprolactone (PCL) blends were investigated in this study. The results showed that hBMSCs existed different morphology on chitosan/PCL blends due to the different adhesion characteristic of
Muhammad Shafiq et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(7), e117-e134 (2018-06-02)
The objective of this study was to develop small-diameter vascular grafts capable of eluting SDF (stromal cell-derived factor)-1α-derived peptide and SP (substance P) for in situ vascular regeneration. Polycaprolactone (PCL)/collagen grafts containing SP or SDF-1α-derived peptide were fabricated by electrospinning.
Chen Jiang et al.
Polymers, 12(11) (2020-10-30)
Electrohydrodynamic (EHD) direct-writing has been widely used to fabricate micro/nanofibers that can serve as a building block in tissue engineering scaffolds. However, the application of EHD direct-writing in tissue engineering is limited by the lack of fundamental knowledge in the
Gerard Rubí-Sans et al.
Biomolecules, 10(1) (2020-01-08)
Degenerative cartilage pathologies are nowadays a major problem for the world population. Factors such as age, genetics or obesity can predispose people to suffer from articular cartilage degeneration, which involves severe pain, loss of mobility and consequently, a loss of
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