441562
反式-1-乙酰基-4-羟基-L-脯氨酸
≥98%, for peptide synthesis
别名:
N-乙酰基-L-羟脯氨酸
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关于此项目
经验公式（希尔记法）:
C7H11NO4
化学文摘社编号:
分子量:
173.17
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
251-780-6
MDL number:
Beilstein/REAXYS Number:
84043
产品名称
反式-1-乙酰基-4-羟基-L-脯氨酸, ≥98%
Quality Level
assay
≥98%
form
powder
optical activity
[α]20/D −119°, c = 4 in H2O
reaction suitability
reaction type: solution phase peptide synthesis
mp
132-133 °C (dec.) (lit.)
application(s)
peptide synthesis
SMILES string
CC(=O)N1C[C@H](O)C[C@H]1C(O)=O
InChI
1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
InChI key
BAPRUDZDYCKSOQ-RITPCOANSA-N
Application
反式-1-乙酰基-4-羟基-L-脯氨酸可用于：
- 4-氟谷氨酸的立体定向合成。
- 合成希佩尔-林道综（VHL）E3泛素连接酶的分子靶点。
- 作为合成假聚（氨基酸）的前体，例如聚（反式-4-羟基-4-酰基-L-脯氨酸酯）和可生物降解的聚合物聚（乳酸-乙醇酸-4-羟脯氨酸）。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Pseudopoly (amino acids): A Study of the Synthesis and Characterization of Poly (trans-4-hydroxy-N-acyl-L-proline esters).
Kwon H Y and Langer R
Macromolecules, 22(8), 3250-3255 (1989)
Synthesis and characterization of a novel biodegradable polymer poly (lactic acid?glycolic acid?4?hydroxyproline).
Duan J, et al.
Journal of Applied Polymer Science, 103(6), 3585-3590 (2007)
Structure-guided design and optimization of small molecules targeting the protein?protein interaction between the von Hippel?Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
Galdeano C, et al.
Journal of Medicinal Chemistry, 57(20), 8657-8663 (2014)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 441562-10G | 04061832594590 |