Quality Level
assay
97%
form
solid
mp
102-104 °C (lit.)
functional group
phosphine oxide
SMILES string
ClP(Cl)(=O)CP(Cl)(Cl)=O
InChI
1S/CH2Cl4O2P2/c2-8(3,6)1-9(4,5)7/h1H2
InChI key
VRXYCDTWIOCJBH-UHFFFAOYSA-N
General description
亚甲基双氯化磷是一种有机磷化合物，常用于膦酰化反应。相比POCl3，反应性更强，反应速率更快。这是由于CH2基的作用(lack of electron back-donation)，造成磷原子中心的亲电性更强。
Application
亚甲基双（二氯膦酸）可用于以下研究：
- 麦考酚亚甲基双（膦酸）衍生物的合成。
- 核苷的膦酰化。
- P,P′-亚甲基双膦酸部分酯化物的制备。
- 亚甲基双膦酸对称双酯和对称四酯的合成。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
supp_hazards
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Aviran Amir et al.
The Journal of organic chemistry, 78(2), 270-277 (2012-12-05)
A new transformation of methylene-bis(phosphonic dichloride) into tetrathiobisphosphonate derivatives is reported. The reaction of methylene-bis(phosphonic dichloride) with 1,2-ethanedithiol in bromoform in the presence of AlCl(3) formed methylene-bis(1,3,2-dithiaphospholane-2-sulfide), which gave rise to O,O'-diester-methylenediphosphonotetrathioate analogues 1a-k upon reaction with phenols and alkyl
Sanjay Bhattarai et al.
Journal of medicinal chemistry, 63(6), 2941-2957 (2020-02-12)
CD73 inhibitors are promising drugs for the (immuno)therapy of cancer. Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor α,β-methylene-ADP (AOPCP) substituted in the 2-position. Small polar or lipophilic residues increased
A direct method for the synthesis of nucleoside 5'-methylenebis (phosphonate) s from nucleosides.
Kalek M, et al.
Tetrahedron Letters, 46(!4), 2417-2421 (2005)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 447714-5G | 04061832288680 |