450510
氧化氘
99.9 atom % D, contains 0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt
别名:
氘代水, 重水
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关于此项目
经验公式（希尔记法）:
D2O
化学文摘社编号:
分子量:
20.03
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12142201
EC Number:
232-148-9
MDL number:
Technique(s):
NMR: suitable
Bp:
101.4 °C (lit.)
产品名称
氧化氘, 99.9 atom % D, contains 0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt
InChI key
XLYOFNOQVPJJNP-ZSJDYOACSA-N
InChI
1S/H2O/h1H2/i/hD2
SMILES string
[2H]O[2H]
isotopic purity
99.9 atom % D
form
liquid
contains
0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt
technique(s)
NMR: suitable
bp
101.4 °C (lit.)
mp
3.8 °C (lit.)
Quality Level
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Application
氧化氘可用于以下过程：
- 作为核磁共振溶剂。
- 制备β -氘代乙醇。
- 在原子反应堆中吸附中子。
- 氘转移剂与六甲基二硅烷结合用于从炔烃制备1,2-二氘代二烯烃。
General description
氧化氘（D 2 O，重水）是含有 0.05 wt.%3-（三甲基硅基）丙酸-2,2,3,3- D 4 酸钠盐的氘代水。它是 D/H 交换反应的氘 (D) 的安全和廉价来源。已测定氢 (H) 与 D 2 O 分子交换氘的平衡常数。据报告表明，在 D 2 O 中制备的明胶凝胶比在水中制备的凝胶具有更高的硬度。采用量热法研究了温度对氘的晶态和液态热容的影响，测定了氘的熔点、熔点焓和熔点熵。目前已经研究了它作为治疗人胰腺癌的潜在药物的用途。
Other Notes
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
美国出口管控产品
此项目有
Andrew J Jezewski et al.
Frontiers in cellular and infection microbiology, 11, 730413-730413 (2021-10-05)
Glycolysis controls cellular energy, redox balance, and biosynthesis. Antiglycolytic therapies are under investigation for treatment of obesity, cancer, aging, autoimmunity, and microbial diseases. Interrupting glycolysis is highly valued as a therapeutic strategy, because glycolytic disruption is generally tolerated in mammals.
Yu-Hsi Lin et al.
Nature metabolism, 2(12), 1413-1426 (2020-11-25)
Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have previously identified a subset of cancers harbouring homozygous deletion of the glycolytic enzyme enolase (ENO1) that have exceptional sensitivity to inhibition of its redundant paralogue, ENO2, through
NMR spectroscopy of saccharide-doped PAGAT dosimeters.
Skyt PS, et al.
Journal of Physics. Conference Series, 573 (2015)
The Exchange Reaction of Hydrogen and Deuterium Oxide.
Crist RH and Dalin GA
J. Chem. Phys. , 2(8), 548-548 (1934)
Thermodynamic properties of deuterium oxide in the temperature range from 6 to 350K.
Smirnova NN, et al.
The Journal of Chemical Thermodynamics, 38(7), 879-883 (2006)
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