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Merck
CN

459224

(S)-α-氨基-γ-丁内酯 盐酸盐

97%

别名:

L-高丝氨酸内酯 盐酸盐, HSI

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关于此项目

经验公式(希尔记法):
C4H7NO2 · HCl
化学文摘社编号:
分子量:
137.56
UNSPSC Code:
12352202
NACRES:
NA.22
PubChem Substance ID:
EC Number:
218-571-1
Beilstein/REAXYS Number:
3562187
MDL number:
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产品名称

(S)-α-氨基-γ-丁内酯 盐酸盐, 97%

InChI key

XBKCXPRYTLOQKS-DFWYDOINSA-N

InChI

1S/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

SMILES string

Cl.N[C@H]1CCOC1=O

assay

97%

form

powder or crystals

optical activity

[α]20/D −27.8°, c = 1 in H2O

mp

210-220 °C (dec.) (lit.)

application(s)

peptide synthesis

Quality Level

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Application

(S)-α-氨基-γ-丁内酯盐酸盐可用于:
  • 作为制备氨基酮醇和β-氨基酸的前体。
  • 通过与取代2-氯-N-苯乙酰胺和不同卤化物反应,制备N-酰化高丝氨酸内酯 (AHL) 类似物。
  • 作为合成L-discadenine的原料。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and β-amino acid derivatives
Gundogdu O, et al.
Tetrahedron Asymmetry, 28(9), 1163-1168 (2017)
Design, synthesis and antibacterial evaluation of novel AHL analogues
Ren J, et al.
Bioorganic & Medicinal Chemistry Letters, 23(14), 4154-4156 (2013)
Natural products from social amoebae
Barnett R and Stallforth P
Chemistry?A European Journal , 24(17), 4202-4214 (2018)
L R Brunham et al.
The pharmacogenomics journal, 14(6), 555-563 (2014-05-28)
Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East
Xuegui Bai et al.
Plant physiology, 158(2), 725-736 (2011-12-06)
N-Acyl-homoserine-lactones (AHLs) are bacterial quorum-sensing signaling molecules that regulate population density. Recent evidence demonstrates their roles in plant defense responses and root development. Hydrogen peroxide (H(2)O(2)), nitric oxide (NO), and cyclic GMP (cGMP) are essential messengers that participate in various

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