463442
4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺
95%
别名:
4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide
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关于此项目
线性分子式:
ClC6H3(OCH3)CONHCH2C6H4SO2NH2
化学文摘社编号:
分子量:
368.84
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
240-722-5
MDL number:
产品名称
4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺, 95%
InChI key
KVWWTCSJLGHLRM-UHFFFAOYSA-N
InChI
1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
SMILES string
COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(N)(=O)=O
assay
95%
mp
209-214 °C (lit.)
functional group
amide
chloro
Quality Level
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General description
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Carlo Marchetti et al.
Journal of cardiovascular pharmacology, 63(4), 316-322 (2013-12-18)
The formation of the NLRP3 inflammasome in the heart during acute myocardial infarction amplifies the inflammatory response and mediates further damage. Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia. The aim
Reply to Letter Regarding Article," NLRP3 Inflammasome as a Therapeutic Target in Myocardial Infarction.
Takahashi M.
International Heart Journal, 55(4), 380-380 (2014)
Molecular regulation of cell fate in cerebral ischemia: role of the inflammasome and connected pathways
Trendelenburg G.
Journal of Cerebral Blood Flow and Metabolism (2014)
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