465119
黄芩素
98%
别名:
5,6,7-三羟基黄酮
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关于此项目
经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
272683
Assay:
98%
Form:
solid
InChI
1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
SMILES string
Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3
InChI key
FXNFHKRTJBSTCS-UHFFFAOYSA-N
assay
98%
form
solid
mp
256-271 °C (lit.)
functional group
ketone, phenyl
Quality Level
Gene Information
mouse ... Hexa(15211)
rat ... Alox15(81639), Alox5(25290)
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General description
黄芩素是黄酮类化合物，是黄嘌呤氧化酶抑制剂。研究了黄芩素在人外周白细胞中的抗炎作用。
Application
黄芩素曾用于研究脂氧合酶的体外定量抑制。
Biochem/physiol Actions
尼泊尔和中日天然药中的黄酮类成分。 黄芩素是黄芩的主要黄酮，可抑制花生四烯酸代谢的12-脂氧合酶（12-LOX）途径，该途径可抑制癌细胞增殖并诱导细胞凋亡。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Naheed Riaz et al.
Phytochemistry, 65(8), 1129-1135 (2004-04-28)
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition
Wujun Dong et al.
Acta pharmaceutica Sinica. B, 10(8), 1576-1585 (2020-09-24)
Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within
Wei-Tien Chang et al.
The American journal of Chinese medicine, 41(2), 315-331 (2013-04-04)
Previous studies suggest baicalein, in addition to its antioxidant effects, protects against hypoxia/reoxygenation injury via its pro-oxidant properties. We hypothesize that a brief period of baicalein treatment prior to ischemia/reperfusion (I/R) may trigger preconditioning protection via a mitochondrial pro-oxidant mechanism.
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes.
Yuh-Chiang Shen et al.
European journal of pharmacology, 465(1-2), 171-181 (2003-03-26)
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied. Both baicalin and baicalein diminished fMLP- or PMA-induced reactive oxygen intermediates production in
Zaijun Zhang et al.
Journal of agricultural and food chemistry, 60(33), 8171-8182 (2012-07-31)
Baicalein, one of the major flavonoids found in Scutellaria baicalensis Georgi, displays neuroprotective effects on experimental models of Parkinson's disease (PD) in vitro and in vivo. Although the antioxidative and/or anti-inflammatory activity of baicalein likely contributes to these neuroprotective effects
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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