467804
羟胺 溶液
50 wt. % in H2O, 99.999%
别名:
HDA
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关于此项目
线性分子式:
NH2OH
化学文摘社编号:
分子量:
33.03
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
232-259-2
MDL number:
Assay:
99.999%
Application
作为制备下列化合物的反应物：
- 心血管药物 Nω-羟基-L-精氨酸（NOHA，一氧化氮前体）的前药
- 羟基氨基胍，作为抗癌药
- 非甾体2,3-二氢喹啉糖皮质激素受体激动剂，具有降低的磷酸烯醇丙酮酸羧基激酶（PEPCK）转录激活活性
- 氧氟沙星的羧酰胺衍生物，具有改善的抗菌特性
- 基于香豆素类似物的TNF-α转化酶（TACE）抑制剂
- HIV整合酶抑制剂
羟胺溶液(NH2OH)可作为反应物用于制备：
- 来自醛类的伯酰胺，通过芳烃钌(II)络合物催化。
- 羟基氨基胍和生物研究用氧氟沙星的甲酰胺衍生物。
- 用于抗体固定化的Fe3O4/Au (GoldMag)纳米颗粒。
General description
羟胺溶液广泛用作有机合成、聚合物行业和水处理领域中的还原剂和抗氧化剂。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
target_organs
Blood, Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Synthesis, characterization and biological activity of a series of carboxamide derivatives of ofloxacin
Arayne MS, et al.
Archives of Pharmacal Research, 33(12), 1901-1909 (2010)
Ruthenium-catalyzed one-pot synthesis of primary amides from aldehydes in water
Garcia-Alvarez R, et al.
Royal Society of Chemistry Advances, 3(17), 5889-5894 (2013)
The synthesis of GoldMag nano-particles and their application for antibody immobilization
Cui Y, et al.
Biomedical Microdevices, 7(2), 153-156 (2005)
Rika Goda et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(5), 828-835 (2006-03-02)
Flutamide (2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide), a nonsteroidal antiandrogen, is used in the treatment of prostate cancer but is occasionally associated with hepatic dysfunction. In the present study, the metabolism of flutamide including the formation of the possible reactive toxic metabolites was investigated using
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