470260
4-甲氧基苯基溴化镁 溶液
0.5 M in THF
别名:
(4-Methoxyphenyl)magnesium bromide, 4-Anisylmagnesium bromide, p-Methoxyphenylmagnesium bromide, Bromo(4-methoxyphenyl)magnesium
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关于此项目
线性分子式:
CH3OC6H4MgBr
化学文摘社编号:
分子量:
211.34
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
产品名称
4-甲氧基苯基溴化镁 溶液, 0.5 M in THF
InChI
1S/C7H7O.BrH.Mg/c1-8-7-5-3-2-4-6-7;;/h3-6H,1H3;1H;/q;;+1/p-1
SMILES string
COc1ccc([Mg]Br)cc1
InChI key
JKXAZEXIOPFJSC-UHFFFAOYSA-M
reaction suitability
reaction type: Grignard Reaction
concentration
0.5 M in THF
bp
65-67 °C
density
0.955 g/mL at 25 °C
Quality Level
Application
4-甲氧基苯基溴化镁是一种通用的格氏试剂，可用于：
- 卟啉去炔化和用镁取代金属中心。
- 合成微管蛋白聚合抑制剂 2-氨基-3,4,5-三甲氧基二苯甲酮。
- （−）-centrolobine 的全合成。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Central nervous system, Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-4.0 °F
flash_point_c
-20 °C
法规信息
危险化学品
此项目有
Two successive one-pot reactions leading to the expeditious synthesis of (−)-centrolobine.
Boulard L, et al.
Tetrahedron Letters, 45(35), 6603-6605 (2004)
Demetalation of Metal Porphyrins via Magnesium Porphyrins by Reaction with Grignard Reagents.
Murakami K, et al.
Chemistry?A European Journal , 19(28), 9123-9126 (2013)
2?Amino?3, 4, 5?Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors.
Chuang H Y, et al.
ChemMedChem, 6(3), 450-456 (2011)
Ryosuke Koyama et al.
Bioorganic & medicinal chemistry, 28(11), 115492-115492 (2020-04-16)
Effective chemotherapy for solid cancers is challenging due to a limitation in permeation that prevents anticancer drugs from reaching the center of the tumor, therefore unable to limit cancer cell growth. To circumvent this issue, we planned to apply the
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