471429
(S)-(-)-α-氨基-γ-丁内酯 氢溴酸盐
99%
别名:
L-高丝氨酸内酯 氢溴酸盐
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关于此项目
经验公式（希尔记法）:
C4H7NO2 · HBr
化学文摘社编号:
分子量:
182.02
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3912375
Assay:
99%
Form:
solid
产品名称
(S)-(-)-α-氨基-γ-丁内酯 氢溴酸盐, 99%
InChI
1S/C4H7NO2.BrH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1
SMILES string
Br[H].N[C@H]1CCOC1=O
InChI key
MKLNTBLOABOJFZ-DFWYDOINSA-N
assay
99%
form
solid
optical activity
[α]20/D −21°, c = 1 in H2O
mp
225 °C (dec.) (lit.)
functional group
ester
storage temp.
2-8°C
Quality Level
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Application
制备用于法尼基蛋白转移酶 以及硒代甲硫氨酸 的假肽抑制剂。
(S)-(-)-α-Amino-γ-butyrolactone hydrobromide may be used as a building block to prepare:
- β-ketoamide N-acylated-L-homoserine lactones (AHLs) as quorum sensing molecules
- p-coumaroyl-HSL (homoserine lactone)
- calpain and lipid peroxidation inhibitors
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A new class of homoserine lactone quorum-sensing signals.
Schaefer AL, et al.
Nature, 454(7204), 595-599 (2008)
Robust routes for the synthesis of N-acylated-L-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity.
Hodgkinson JT, et al.
Tetrahedron Letters, 52(26), 3291-3294 (2011)
Koch, T. Buchardt, O.
Synthesis, 1065-1065 (1993)
S L Graham et al.
Journal of medicinal chemistry, 37(6), 725-732 (1994-03-18)
Inhibitors of Ras farnesyl-protein transferase are described. These are reduced pseudopeptides related to the C-terminal tetrapeptide of the Ras protein that signals farnesylation. Deletion of the carbonyl groups between the first two residues of the tetrapeptides either preserves or improves
Novel dual inhibitors of calpain and lipid peroxidation.
Auvin S, et al.
Bioorganic & Medicinal Chemistry Letters, 14(14), 3825-3828 (2004)
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