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经验公式(希尔记法):
C3H6O2
化学文摘社编号:
分子量:
74.08
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
79783
产品名称
(S)-(-)-缩水甘油, 97%, optical purity ee: 98% (GLC)
InChI
1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2/t3-/m0/s1
SMILES string
OC[C@H]1CO1
InChI key
CTKINSOISVBQLD-VKHMYHEASA-N
assay
97%
optical activity
[α]20/D −15°, neat
optical purity
ee: 98% (GLC)
refractive index
n20/D 1.433 (lit.)
bp
66-67 °C/19 mmHg (lit.)
density
1.116 g/mL at 20 °C (lit.)
functional group
ether
hydroxyl
storage temp.
−20°C
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Application
用于合成手性 (E)-烯丙醇侧链,该侧链可通过交叉复分解反应引入到前列环素和前列腺素骨架中。
General description
缩水甘油或称2,3-环氧-1-丙醇是一种具有高反应活性的环氧衍生物,通常用作制备多种聚合物(如聚酯、聚碳酸酯、聚氨酯和聚酰胺)的单体。它还被用于制备洗涤剂、橡胶、香水、纺织物染料、清漆、化妆品和油漆。
signalword
Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
161.6 °F
flash_point_c
72 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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One-pot synthesis of glycidol from glycerol and dimethyl carbonate over KF/sepiolite catalyst
Algoufi YT, et al.
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Neil A Sheddan et al.
Organic letters, 8(14), 3101-3104 (2006-06-30)
[reaction: see text] A cross metathesis (CM) approach has been successfully applied to introduce fully functionalized omega-side chain appendages of various prostacyclin and prostaglandin analogues, resulting in high (E)-selectivities for the C13-C14 double bond and leading to the total syntheses
Nicolas M B Brancucci et al.
Cell, 171(7), 1532-1544 (2017-11-14)
Transmission represents a population bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production
Troy D Haines et al.
Journal of the American Oil Chemists' Society, 88(1), 1-14 (2011-02-26)
Analysis of MCPD esters and glycidyl esters in vegetable oils using the indirect method proposed by the DGF gave inconsistent results when salting out conditions were varied. Subsequent investigation showed that the method was destroying and reforming MCPD during the
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