47674
FFmoc-N-三苯甲基-L-谷氨酰胺
≥98.0% (HPLC), for peptide synthesis
别名:
Nα-Fmoc-Nδ-三苯甲基-L-谷氨酰胺
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关于此项目
经验公式（希尔记法）:
C39H34N2O5
CAS Number:
分子量:
610.70
Beilstein:
4343953
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26
Product Name
FFmoc-N-三苯甲基-L-谷氨酰胺, ≥98.0% (HPLC)
质量水平
方案
≥98.0% (HPLC)
表单
powder
旋光性
[α]/D -14.0±1.5°, c = 1% in DMF
反应适用性
reaction type: Fmoc solid-phase peptide synthesis
应用
peptide synthesis
官能团
Fmoc
储存温度
2-8°C
SMILES字符串
OC(=O)[C@H](CCC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46
InChI
1S/C39H34N2O5/c42-36(41-39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29)25-24-35(37(43)44)40-38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34/h1-23,34-35H,24-26H2,(H,40,45)(H,41,42)(H,43,44)/t35-/m0/s1
InChI key
WDGICUODAOGOMO-DHUJRADRSA-N
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一般描述
Fmoc-Gln(Trt)-OH 也称 Nα-Fmoc-Nδ-三苯甲基-L-谷氨酰胺，它是 Fmoc 保护的氨基酸衍生物，可用作合成肽的试剂。 由于谷氨酰胺受到三苯甲基保护，因此可以防止在反应中出现不需要的取代产物。
应用
Fmoc-Gln(Trt)-OH可用作Fmoc 固相肽合成的原料，用于合成fellutamide B 和 fellutamide B的N-辛酰基类似物。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
个人防护装备
Eyeshields, Gloves, type N95 (US)
Protection of carboxamide functions by the trityl residue. Application to peptide synthesis
P Sieber, et.al.
Tetrahedron Letters, 32, 739-742 (1991)
Neurotrophic peptide aldehydes: Solid phase synthesis of fellutamide B and a simplified analog
JS Schneekloth
Bioorganic & Medicinal Chemistry Letters, 16, 3855-3858 (2006)
Cathleen Jendrny et al.
Chembiochem : a European journal of chemical biology, 17(8), 719-726 (2015-11-18)
Serpin proteins irreversibly inhibit serine proteases, but only a small part of the serpin reactive-center loop (RCL) is responsible for the initial protein-protein interaction (PPI). To develop peptidic protease inhibitors, kallikrein-related peptidases 7 (KLK7) and 5 (KLK5) were chosen. Firstly
Marcus Pickhardt et al.
Current Alzheimer research, 14(7), 742-752 (2017-02-06)
Anti-aggregation drugs play an important role in therapeutic approaches for Alzheimer's disease. We have previously developed a number of compounds that are able to inhibit the pathological aggregation of Tau protein. One common obstacle to application is the limited penetration
Hong Cheng et al.
Macromolecular bioscience, 19(4), e1800410-e1800410 (2018-12-24)
In this paper, a self-delivery chimeric peptide PpIX-PEG8 -KVPRNQDWL is designed for photodynamic therapy (PDT) amplified immunotherapy against malignant melanoma. After self-assembly into nanoparticles (designated as PPMA), this self-delivery system shows high drug loading rate, good dispersion, and stability as
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