assay
98%
mp
131-134 °C (lit.)
SMILES string
OC(=O)c1cc(F)ccc1[N+]([O-])=O
InChI
1S/C7H4FNO4/c8-4-1-2-6(9(12)13)5(3-4)7(10)11/h1-3H,(H,10,11)
InChI key
GHYZIXDKAPMFCS-UHFFFAOYSA-N
General description
5-Fluoro-2-nitrobenzoic acid, an ortho-nitro benzoic acid derivative, can be prepared by the oxidation of 5-fluoro-2-nitrotoluene. It is an intermediate formed during the synthesis of N1-(2,4-dichlorophenyl)-2-amino-5-fluorobenzamide. It participates in the synthesis of novel quinazolinones that are potential inhibitors of p38α mitogen-activated protein kinase (MAPK).
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Solution and solid-phase approaches to quinconazole and fluquinconazole-inhibitors of fungal ergosterol biosynthesis.
Bilokin YV and Kovalenko SM.
Heterocyclic Communications, 6(5), 409-414 (2000)
Dearg S Brown et al.
Bioorganic & medicinal chemistry letters, 22(12), 3879-3883 (2012-05-23)
A novel, potent and selective quinazolinone series of inhibitors of p38α MAP kinase has been identified. Modifications designed to address the issues of poor aqueous solubility and high plasma protein binding as well as embedded aniline functionalities resulted in the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 481904-5G | 04061831830002 |