482641
(S)-(+)-2-氟-α-甲基-4-联苯乙酸
98%
别名:
(S)-(+)-氟比洛芬
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
线性分子式:
C6H5C6H3(F)CH(CH3)CO2H
化学文摘社编号:
分子量:
244.26
UNSPSC Code:
12352000
PubChem Substance ID:
EC Number:
257-263-1
MDL number:
assay
98%
optical activity
[α]24/D +43°, c = 1 in chloroform
mp
109-110 °C (lit.)
SMILES string
C[C@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2
Gene Information
human ... IL8RA(3577)
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Ilaria Peretto et al.
Journal of medicinal chemistry, 48(18), 5705-5720 (2005-09-02)
Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD)
Nicholas Stock et al.
Bioorganic & medicinal chemistry letters, 16(8), 2219-2223 (2006-02-04)
The subtle modification of a selection of Abeta42 inhibiting non-steroidal anti-inflammatory drugs (NSAIDs), through synthesis of the geminal dimethyl analogues, was anticipated to ablate their cyclooxygenase activity whilst maintaining Abeta42 inhibition. Methylflurbiprofen 6 exhibited similar in vitro Abeta42 inhibition to
Marcello Allegretti et al.
Journal of medicinal chemistry, 48(13), 4312-4331 (2005-06-25)
The CXC chemokine CXCL8/IL-8 plays a major role in the activation and recruitment of polymorphonuclear (PMN) cells at inflammatory sites. CXCL8 activates PMNs by binding the seven-transmembrane (7-TM) G-protein-coupled receptors CXC chemokine receptor 1 (CXCR1) and CXC chemokine receptor 2