489689
3-甲基-5-异噁唑乙酸
98%
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关于此项目
经验公式（希尔记法）:
C6H7NO3
化学文摘社编号:
分子量:
141.12
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
产品名称
3-甲基-5-异噁唑乙酸, 98%
InChI
1S/C6H7NO3/c1-4-2-5(10-7-4)3-6(8)9/h2H,3H2,1H3,(H,8,9)
SMILES string
Cc1cc(CC(O)=O)on1
InChI key
POEFJFLAFQWOTL-UHFFFAOYSA-N
assay
98%
mp
101-104 °C (lit.)
functional group
carboxylic acid
Application
3-Methyl-5-isoxazoleacetic acid may be used as a reagent in the solid phase synthesis of von Hippel-Lindau protein (VHL) ligands. It may also be used to prepare (N-(4-chlorophenyl)-α-[[(4-chlorophenyl)amino]methylene]-3-methyl-5-isoxazoleacetamide).
General description
3-Methyl-5-isoxazoleacetic acid is a substituted isoxazole.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Dennis L Buckley et al.
Journal of the American Chemical Society, 134(10), 4465-4468 (2012-03-01)
E3 ubiquitin ligases, which bind protein targets, leading to their ubiquitination and subsequent degradation, are attractive drug targets due to their exquisite substrate specificity. However, the development of small-molecule inhibitors has proven extraordinarily challenging as modulation of E3 ligase activities
Timothy B Johnstone et al.
The Journal of pharmacology and experimental therapeutics, 336(3), 908-915 (2010-12-17)
α5 Subunit-containing GABA(A) receptors (GABA(A)Rs) and α7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and attentional processes in the hippocampus. α5 GABA(A)Rs alter network activity by tonic inhibition of
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