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Merck
CN

490024

L-谷氨酰胺-(氨基-15N)

98 atom % 15N

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线性分子式:
H215NCO(CH2)2CH(NH2)CO2H
化学文摘社编号:
分子量:
147.14
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
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产品名称

L-谷氨酰胺-(氨基-15N), 98 atom % 15N

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i7+1

SMILES string

N[C@@H](CCC([15NH2])=O)C(O)=O

InChI key

ZDXPYRJPNDTMRX-QQKKVIQDSA-N

isotopic purity

98 atom % 15N

assay

99% (CP)

form

solid

optical activity

[α]25/D +33.0°, c = 2 in 5 M HCl

mp

185 °C (dec.) (lit.)

mass shift

M+1

Quality Level

Biochem/physiol Actions

L-谷氨酰胺是氮的来源,主要参与合成蛋白质、肽、嘌呤、嘧啶、核苷酸、核酸和神经递质的主要前体。它充当免疫系统淋巴细胞和巨噬细胞增殖,肠组织维持肠道完整性和胰岛素产生的燃料。(4)(3)应激条件下骨骼肌会释放L-谷氨酰胺。

General description

L-谷氨酰胺是一种支链、非必需氨基酸。它是中枢神经系统(CNS)、血浆和人体骨骼肌中含量最丰富的氨基酸之一。(2)L-谷氨酰胺是由谷氨酰胺合成酶催化谷氨酸转氨化合成的。

Packaging

该产品可以大包装形式供货,也可按需进行包装。 如需关于价格、供货形式及包装的信息,请联系稳定同位素客户服务

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Glutamine and glutamate as vital metabolites
Newsholme P, et al.
Brazilian journal of medical and biological research, 36(2), 153-163 (2003)
The influence of oral L-glutamine supplementation on muscle strength recovery and soreness following unilateral knee extension eccentric exercise
Legault Z, et al.
International Journal of Sport Nutrition and Exercise Metabolism, 25(5), 417-426 null
Katarzyna Dąbrowska et al.
Neurochemistry international, 118, 225-232 (2018-07-19)
SN1, a system N amino acid transporter specific for astrocytes, is mainly responsible for export of newly synthesized L-glutamine from the cells. Astrocytic retention of L-glutamine which plays a critical role in ammonia-induced astrocytic swelling resulting in brain edema, could
Liangxian Cao et al.
Molecular cancer therapeutics, 18(1), 3-16 (2018-10-26)
PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, we performed extensive biological characterization of the activity of PTC299 and
Min Yuan et al.
Nature protocols, 14(2), 313-330 (2019-01-27)
Targeted tandem mass spectrometry (LC-MS/MS) has been extremely useful for profiling small molecules extracted from biological sources, such as cells, bodily fluids and tissues. Here, we present a protocol for analysing incorporation of the non-radioactive stable isotopes carbon-13 (13C) and

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