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Merck
CN

498785

2-甲氧基苄基氯化锌 溶液

0.5 M in THF

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线性分子式:
CH3OC6H4CH2ZnCl
化学文摘社编号:
分子量:
222.00
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
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InChI

1S/C8H9O.ClH.Zn/c1-7-5-3-4-6-8(7)9-2;;/h3-6H,1H2,2H3;1H;/q;;+1/p-1

SMILES string

COc1ccccc1C[Zn]Cl

InChI key

NRJJPCZGLGLMEV-UHFFFAOYSA-M

concentration

0.5 M in THF

density

0.937 g/mL at 25 °C

storage temp.

2-8°C

Application

2-Methoxybenzylzinc chloride can be used as:
  • An intermediate in the preparation of 2,4-diamino-6-arylmethylquinazolines as possible DHFR inhibitors.
  • A model organozinc compound in the Pd-catalyzed synthesis of α-aryl tertiary amides by reacting with carbamoyl chlorides.
  • A substrate in the synthesis of forensically significant pyridine and pyrimidine derivatives.

Legal Information

Rieke® Metals, Inc. 产品 ®Rieke Metals, Inc. 的注册商标

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

存储类别

3 - Flammable liquids

wgk

WGK 3

flash_point_f

1.0 °F - closed cup

flash_point_c

-17.22 °C - closed cup

法规信息

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分析证书(COA)

Lot/Batch Number

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Suzuki-Miyaura and Negishi approaches to a series of forensically relevant pyridines and pyrimidines
Blachut D, et al.
Synthesis, 2011(21), 3496-3506 (2011)
Preparation of tertiary amides via aryl, heteroaryl, and benzyl organozinc reagents; scope and limitations
Rieke RD and Kim S
Tetrahedron Letters, 53(27), 3478-3481 (2012)
A novel method of synthesis of 2, 4-diamino-6-arylmethylquinazolines using palladium (0)-catalyzed organozinc chemistry
Rosowsky A and Chen H
The Journal of Organic Chemistry, 66(22), 7522-7526 (2001)

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