525057
4-吡唑硼酸频哪醇酯
97%
别名:
4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷
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关于此项目
线性分子式:
(CH3)4C2O2BC3N2H3
化学文摘社编号:
分子量:
194.04
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
InChI
1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)
SMILES string
CC1(C)OB(OC1(C)C)c2cn[nH]c2
InChI key
TVOJIBGZFYMWDT-UHFFFAOYSA-N
assay
97%
form
solid
mp
142-146 °C (lit.)
Quality Level
Application
试剂用于
用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
- Suzuki-Miyaura 交叉耦合
- 钌催化不对称氢化
用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
- VEGF
- 极光
- Rho（岩石）
- Janus 激酶 2 (JAK)
- c-MET
- ALK
- S-亚硝基谷胱甘肽还原酶
- CDC7
- 乙酰辅酶A羧化酶
- 促存活 Bcl-2 蛋白
- 病毒 RNA 依赖性 RNA 聚合酶
- 长链脂肪酸延长酶 6
- PI3
- AKT
- Chk1
- 蛋白激酶 B
Legal Information
Boron Molecular 制造
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Discovery of Novel Benzoxazinones as Potent and Orally Active Long Chain Fatty Acid Elongase 6 Inhibitors
Mizutani, T.; et al.
Journal of Medicinal Chemistry, 52, 7989-7300 (2009)
Benjamin Perry et al.
Bioorganic & medicinal chemistry letters, 18(19), 5299-5302 (2008-09-09)
Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.
Jesus R Medina et al.
Bioorganic & medicinal chemistry letters, 20(8), 2552-2555 (2010-03-26)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, depending on the substitution pattern, may or may not exert
Gordon Saxty et al.
Journal of medicinal chemistry, 50(10), 2293-2296 (2007-04-25)
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach.
Dirk A Heerding et al.
Journal of medicinal chemistry, 51(18), 5663-5679 (2008-09-20)
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monotherapy
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