525057
4-吡唑硼酸频哪醇酯
97%
别名:
4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷
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关于此项目
线性分子式:
(CH3)4C2O2BC3N2H3
化学文摘社编号:
分子量:
194.04
MDL编号:
UNSPSC代码:
12352103
PubChem化学物质编号:
NACRES:
NA.22
方案
97%
表单
solid
mp
142-146 °C (lit.)
SMILES字符串
CC1(C)OB(OC1(C)C)c2cn[nH]c2
InChI
1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)
InChI key
TVOJIBGZFYMWDT-UHFFFAOYSA-N
应用
试剂用于
用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
- Suzuki-Miyaura 交叉耦合
- 钌催化不对称氢化
用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
- VEGF
- 极光
- Rho（岩石）
- Janus 激酶 2 (JAK)
- c-MET
- ALK
- S-亚硝基谷胱甘肽还原酶
- CDC7
- 乙酰辅酶A羧化酶
- 促存活 Bcl-2 蛋白
- 病毒 RNA 依赖性 RNA 聚合酶
- 长链脂肪酸延长酶 6
- PI3
- AKT
- Chk1
- 蛋白激酶 B
法律信息
Boron Molecular 制造
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Inhibition of acetyl-CoA carboxylases has the potential for modulating long chain fatty acid biosynthesis and mitochondrial fatty acid oxidation. Hybridization of weak inhibitors of ACC2 provided a novel, moderately potent but lipophilic series. Optimization led to compounds 33 and 37
Dirk A Heerding et al.
Journal of medicinal chemistry, 51(18), 5663-5679 (2008-09-20)
Overexpression of AKT has an antiapoptotic effect in many cell types, and expression of dominant negative AKT blocks the ability of a variety of growth factors to promote survival. Therefore, inhibitors of AKT kinase activity might be useful as monotherapy
Robert M Garbaccio et al.
Bioorganic & medicinal chemistry letters, 17(22), 6280-6285 (2007-09-29)
From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered basic amine designed to
Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases
Matthews, T. P.; et al.
Bioorganic & Medicinal Chemistry, 20, 4045-4049 (2010)
Gordon Saxty et al.
Journal of medicinal chemistry, 50(10), 2293-2296 (2007-04-25)
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach.
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