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Merck
CN

525057

Sigma-Aldrich

4-吡唑硼酸频哪醇酯

97%

别名:

4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷

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关于此项目

线性分子式:
(CH3)4C2O2BC3N2H3
CAS Number:
269410-08-4
分子量:
194.04
MDL编号:
MFCD03453063
UNSPSC代码:
12352103
PubChem化学物质编号:
24874465
NACRES:
NA.22

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质量水平

100

方案

97%

表单

solid

mp

142-146 °C (lit.)

SMILES字符串

CC1(C)OB(OC1(C)C)c2cn[nH]c2

InChI

1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)

InChI key

TVOJIBGZFYMWDT-UHFFFAOYSA-N

相关类别

应用

试剂用于
  • Suzuki-Miyaura 交叉耦合
  • 钌催化不对称氢化

用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
  • VEGF
  • 极光
  • Rho（岩石）
  • Janus 激酶 2 (JAK)
  • c-MET
  • ALK
  • S-亚硝基谷胱甘肽还原酶
  • CDC7
  • 乙酰辅酶A羧化酶
  • 促存活 Bcl-2 蛋白
  • 病毒 RNA 依赖性 RNA 聚合酶
  • 长链脂肪酸延长酶 6
  • PI3
  • AKT
  • Chk1
  • 蛋白激酶 B

法律信息

Boron Molecular 制造

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV4721
MKCV3914
MKCQ2654
MKCM6467
MKCL2019

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Optimization of the cellular and pharmacological activity of a novel series of PI3 kinase inhibitors targeting multiple isoforms is described.
Gordon Saxty et al.
Journal of medicinal chemistry, 50(10), 2293-2296 (2007-04-25)
Using fragment-based screening techniques, 5-methyl-4-phenyl-1H-pyrazole (IC50 80 microM) was identified as a novel, low molecular weight inhibitor of protein kinase B (PKB). Herein we describe the rapid elaboration of highly potent and ligand efficient analogues using a fragment growing approach.
Discovery of Novel Benzoxazinones as Potent and Orally Active Long Chain Fatty Acid Elongase 6 Inhibitors
Mizutani, T.; et al.
Journal of Medicinal Chemistry, 52, 7989-7300 (2009)
Jesus R Medina et al.
Bioorganic & medicinal chemistry letters, 20(8), 2552-2555 (2010-03-26)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, depending on the substitution pattern, may or may not exert
J Jean Cui et al.
Journal of medicinal chemistry, 54(18), 6342-6363 (2011-08-05)
Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal structure of 3 (PHA-665752), bound to c-MET kinase domain, revealed a novel ATP site
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