526304
聚合物负载氰基硼氢化物
macroporous, 20-50 mesh, extent of labeling: ~2.0-3.5 mmol/g loading
别名:
Amberlite™ IRA-400 负载氰基硼氢化物
form
macroporous
reaction suitability
reaction type: solution phase peptide synthesis, reactivity: imine reactive
extent of labeling
~2.0-3.5 mmol/g loading
particle size
20-50 mesh
mp
>300 °C (lit.)
storage temp.
2-8°C
Quality Level
General description
Cyanoborohydride, polymer supported: is a polymer-supported reducing agent used in reductive amination reactions at room temperature.
Application
Polymer supported cyanoborohydride (PSCBH) has been used in the reductive alkylation aminocyclitols for the preparation of corresponding secondary amines.
It can also be used:
It can also be used:
- In combination with manganese dioxide (MnO2) for one-pot conversion of alcohols to secondary or tertiary amines.
- In the synthesis of natural products, (±)-oxomaritidine and (±)-epimaritidine.
Legal Information
Amberlite is a trademark of DuPont de Nemours, Inc.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ley, S.V.
J. Chem. Soc., Perkin Trans., 2239-2239 (1998)
Synthesis of the alkaloids (?)-oxomaritidine and (?)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents
Ley S, et al.
Journal of the Chemical Society. Perkin Transactions 1, 3(10), 1251-1252 (1999)
Habermann, J.
J. Chem. Soc., Perkin Trans., 3127-3127 (1998)
Small-Scale One-Pot Reductive Alkylation of Unprotected Aminocyclitols with Supported Reagents
Sisa M, et al.
Synthesis, 2008(19), 3167-3170 (2008)
In situ oxidation- imine formation- reduction routes from alcohols to amines
Blackburn L and Taylor RJK
Organic Letters, 3(11), 1637-1639 (2001)
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