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Merck
CN

527254

三甲基硅烷化重氮甲烷 溶液

2.0 M in diethyl ether

别名:

TMS-重氮甲烷溶液, (三甲硅烷)重氮甲烷

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关于此项目

线性分子式:
(CH3)3SiCHN2
化学文摘社编号:
分子量:
114.22
UNSPSC Code:
12352302
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1902903
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InChI

1S/C4H10N2Si/c1-7(2,3)4-6-5/h4H,1-3H3

SMILES string

C[Si](C)(C)C=[N+]=[N-]

InChI key

ONDSBJMLAHVLMI-UHFFFAOYSA-N

concentration

2.0 M in diethyl ether

density

0.773 g/mL at 25 °C

storage temp.

2-8°C

General description

(三甲基硅烷基)重氮甲烷被认为是重氮甲烷的非爆炸性替代物,用于羰基衍生物(主要是酮)通过反应(如 Tiffeneau-Demjanov 重排)的同系化。

Application

反应物用于制备:
  • 改善代谢稳定性和抗菌活性的天然产物大环内酯 (-)-A26771B 的大内酰胺类似物
  • 白霉素 D 类似物作为蛋白激酶抑制剂用于肿瘤治疗
  • 非天然 α-含 gem-二膦酸盐的氨基酸衍生物通过 Michael 加成反应
  • 作为潜在透明质酸酶底物的封端 4-甲基伞形酮基透明质酸二糖和四糖
  • Stictamides A-C 作为具有抗肿瘤侵袭活性的基质金属肽酶 12 (MMP12) 抑制剂
  • 内皮素转换酶 (ECE) 抑制剂 WS 75624A 和 WS 75624B(通过交叉转移方法)
  • 贝壳杉烯衍生物作为抗炎剂
  • 毛叶假鹰爪素 C 类似物作为强效抗肿瘤药物通过激活纺锤体组装检查点发挥作用
  • 咪唑并 [2,1-b] 苯并噻唑衍生物作为潜在的 p53 抑制剂

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Lungs

supp_hazards

存储类别

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-31.0 °F - closed cup

flash_point_c

-35 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

监管及禁止进口产品
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