536954
迷迭香酸
96%
别名:
(R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸, 3,4-二羟基肉桂酸 ( R )-1-羧基-2-（3,4-二羟基苯基）乙酯
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关于此项目
经验公式（希尔记法）:
C18H16O8
化学文摘社编号:
分子量:
360.31
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2227587
产品名称
迷迭香酸, 96%
form
powder
InChI
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
SMILES string
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
InChI key
DOUMFZQKYFQNTF-WUTVXBCWSA-N
assay
96%
mp
171-175 °C (lit.)
functional group
carboxylic acid
ester
Quality Level
Gene Information
human ... LCK(3932)
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Application
迷迭香酸被用作模型化合物，以研究其在动物模型中的生物学效应。多项研究表明其具有以下作用：
- 抑制肾病。
- 抑制硫酸庆大霉素（GS）诱导的肾脏氧化损伤。
- 缓解噪音引起的听力损失。
- 缓解抑郁。
- 缓解创伤后应激障碍（PTSD）样症状。
General description
迷迭香酸是一种具有抗氧化和抗炎作用的生物活性植物酚类化合物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Nie H, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 51, 16-22 (2014)
Rosmarinic acid ameliorates diabetic nephropathy in uninephrectomized diabetic rats.
Tavafi M, et al.
Iranian Journal of Basic Medical Sciences, 14(3), 275-275 (2011)
Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea.
Fetoni A R, et al.
Free Radical Biology & Medicine, 83, 269-281 (2015)
Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats.
Tavafi M and Ahmadvand H
Tissue & cell, 43(6), 392-397 (2011)
Potential Albumin-Based Antioxidant Nanoformulations for Ocular Protection against Oxidative Stress.
Daseul Kim et al.
Pharmaceutics, 11(7) (2019-06-30)
Amongst various drug administration methods, ophthalmic drug delivery has been a useful way for the treatment of eye-related diseases. However, therapeutic efficacy of ocular therapy for anterior or posterior eye segments through topical administration is considerably challenged by the number
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