536954
迷迭香酸
96%
别名:
(R)-O-(3,4-二羟基肉桂酰)-3-(3,4-二羟苯基)乳酸, 3,4-二羟基肉桂酸 ( R )-1-羧基-2-（3,4-二羟基苯基）乙酯
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关于此项目
经验公式（希尔记法）:
C18H16O8
化学文摘社编号:
分子量:
360.31
Beilstein:
2227587
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.22
方案
96%
表单
powder
mp
171-175 °C (lit.)
官能团
carboxylic acid
ester
SMILES字符串
OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
InChI
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
InChI key
DOUMFZQKYFQNTF-WUTVXBCWSA-N
基因信息
human ... LCK(3932)
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一般描述
迷迭香酸是一种具有抗氧化和抗炎作用的生物活性植物酚类化合物。
应用
迷迭香酸被用作模型化合物，以研究其在动物模型中的生物学效应。多项研究表明其具有以下作用：
- 抑制肾病。
- 抑制硫酸庆大霉素（GS）诱导的肾脏氧化损伤。
- 缓解噪音引起的听力损失。
- 缓解抑郁。
- 缓解创伤后应激障碍（PTSD）样症状。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Effect of rosmarinic acid on inhibition of gentamicin induced nephrotoxicity in rats.
Tavafi M and Ahmadvand H
Tissue & cell, 43(6), 392-397 (2011)
Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea.
Fetoni A R, et al.
Free Radical Biology & Medicine, 83, 269-281 (2015)
Rosmarinic acid ameliorates PTSD-like symptoms in a rat model and promotes cell proliferation in the hippocampus.
Nie H, et al.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 51, 16-22 (2014)
Potential Albumin-Based Antioxidant Nanoformulations for Ocular Protection against Oxidative Stress.
Daseul Kim et al.
Pharmaceutics, 11(7) (2019-06-30)
Amongst various drug administration methods, ophthalmic drug delivery has been a useful way for the treatment of eye-related diseases. However, therapeutic efficacy of ocular therapy for anterior or posterior eye segments through topical administration is considerably challenged by the number
Rosmarinic acid ameliorates diabetic nephropathy in uninephrectomized diabetic rats.
Tavafi M, et al.
Iranian Journal of Basic Medical Sciences, 14(3), 275-275 (2011)
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