Merck
CN
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文件

539112

Sigma-Aldrich

4-溴-1-氟-2-硝基苯

96%

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线性分子式:
BrC6H3(F)NO2
CAS号:
364-73-8
分子量:
220.00
MDL编号:
MFCD00129165
PubChem化学物质编号:
24878380
NACRES:
NA.22

质量水平

100

检测方案

96%

折射率

n20/D 1.575 (lit.)

bp

240-241 °C (lit.)

mp

18-19 °C (lit.)

密度

1.786 g/mL at 25 °C (lit.)

SMILES string

[O-][N+](=O)c1cc(Br)ccc1F

InChI

1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H

InChI key

UQEANKGXXSENNF-UHFFFAOYSA-N

相关类别

一般描述

4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.

应用

4-Bromo-1-fluoro-2-nitrobenzene may be used in the synthesis of:
  • 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol
  • 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile
  • dibenzoxazepine analog, as potent sodium channel blocker
  • 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester
Used in the synthesis of anti-inflammatory agents.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

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Stephen M Lynch et al.
Bioorganic & medicinal chemistry letters, 25(1), 43-47 (2014-12-04)
We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.
Erik Rytter Ottosen et al.
Journal of medicinal chemistry, 46(26), 5651-5662 (2003-12-12)
We wish to report the synthesis and structure-activity relationship (SAR) of a series of 4-aminobenzophenones, as a novel compound class with high antiinflammatory activity. Our initial lead, (4-[(2-aminophenyl)amino]phenyl)(phenyl)methanone (3), was systematically optimized and resulted in compounds that potently inhibited the
Venkateshwarlu Gurram et al.
Advanced synthesis & catalysis, 357(2-3), 451-462 (2015-03-03)
Benzotriazoles are a highly important class of compounds with broad-ranging applications in such diverse areas as medicinal chemistry, as auxiliaries in organic synthesis, in metallurgical applications, in aircraft deicing and brake fluids, and as antifog agents in photography. Although there
Tomoki Kawai et al.
Nuclear medicine and biology, 40(5), 705-709 (2013-05-28)
As a first trial for in vivo imaging of β-secretase (BACE1) in Alzheimer's disease brain, we applied a novel non-peptidergic small molecule which has high affinity to the enzyme, naphthalene-1-carboxylic acid (3'-chloro-4'-fluoro-4-piperazin-1-yl-biphenyl-3-yl)amide (NCFB) into positron emission tomography (PET) probe. In
Katie M Lutker et al.
Crystal growth & design, 8(1), 136-139 (2008-01-01)
Bis(5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrilyl)acetylene, a derivative of the highly polymorphic compound 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) that possesses two chromophores electronically coupled through a triple bond, was found to be trimorphic. Structural data for two of these forms indicates that symmetry is maintained in one structure
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