545740
(R)-(-)-2-氟-α-甲基-4-联苯乙酸
97%
别名:
(R)-2-氟比洛芬, 氟比洛芬
登录 查看组织和合同定价。
选择尺寸
关于此项目
线性分子式:
C6H5C6H3(F)CH(CH3)CO2H
化学文摘社编号:
分子量:
244.26
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
EC Number:
257-264-7
MDL number:
Assay:
97%
InChI key
SYTBZMRGLBWNTM-SNVBAGLBSA-N
InChI
1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
SMILES string
C[C@@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2
assay
97%
mp
110-113 °C (lit.)
Quality Level
Gene Information
human ... APH1A(51107), APH1B(83464), IL8RA(3577), NCSTN(23385), PSEN1(5663), PSEN2(5664), PSENEN(55851)
Biochem/physiol Actions
γ-分泌酶抑制剂；淀粉样 Aβ 42 降低剂
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Repr. 2 - Skin Sens. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Natasja de Bruin et al.
Chirality, 30(5), 632-641 (2018-02-07)
Flurbiprofen (F) is a nonsteroidal anti-inflammatory drug (NSAID) used therapeutically as the racemate of (R)-enantiomer and (S)-enantiomer. The inversion of RF to SF and vice versa was investigated in C57Bl/6 and SJL mice and Dark Agouti and Lewis rats. The
Christensen, D.D.
The Journal of Clinical Psychiatry, 9, 32-32 (2007)
Thomas L Kukar et al.
Nature, 453(7197), 925-929 (2008-06-13)
Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease. To identify the target of these agents we developed
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持