545740
(R)-(-)-2-氟-α-甲基-4-联苯乙酸
97%
别名:
(R)-2-氟比洛芬, 氟比洛芬
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关于此项目
线性分子式:
C6H5C6H3(F)CH(CH3)CO2H
化学文摘社编号:
分子量:
244.26
EC 号:
MDL编号:
UNSPSC代码:
12352101
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
97%
mp
110-113 °C (lit.)
SMILES字符串
C[C@@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI
1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChI key
SYTBZMRGLBWNTM-SNVBAGLBSA-N
基因信息
human ... APH1A(51107), APH1B(83464), IL8RA(3577), NCSTN(23385), PSEN1(5663), PSEN2(5664), PSENEN(55851)
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生化/生理作用
γ-分泌酶抑制剂；淀粉样 Aβ 42 降低剂
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Repr. 2 - Skin Sens. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Christensen, D.D.
The Journal of Clinical Psychiatry, 9, 32-32 (2007)
Natasja de Bruin et al.
Chirality, 30(5), 632-641 (2018-02-07)
Flurbiprofen (F) is a nonsteroidal anti-inflammatory drug (NSAID) used therapeutically as the racemate of (R)-enantiomer and (S)-enantiomer. The inversion of RF to SF and vice versa was investigated in C57Bl/6 and SJL mice and Dark Agouti and Lewis rats. The
Thomas L Kukar et al.
Nature, 453(7197), 925-929 (2008-06-13)
Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such as some non-steroidal anti-inflammatory drugs, is a promising therapeutic approach for Alzheimer's disease. To identify the target of these agents we developed
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