55088
8-羟基喹啉-2-羧酸
≥98.0% (HPLC)
别名:
8-羟基-2-喹啉甲酸
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关于此项目
经验公式（希尔记法）:
C10H7NO3
化学文摘社编号:
分子量:
189.17
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
146082
Assay:
≥98.0% (HPLC)
Form:
solid
InChI
1S/C10H7NO3/c12-8-3-1-2-6-4-5-7(10(13)14)11-9(6)8/h1-5,12H,(H,13,14)
SMILES string
OC(=O)c1ccc2cccc(O)c2n1
InChI key
UHBIKXOBLZWFKM-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
form
solid
functional group
carboxylic acid
Quality Level
General description
8-Hydroxy-2-quinolinecarboxylic acid (8HQC) is a tridentate chelating agent. It reacts with 2-aminophenol to form a benzoxazole derivative, which can undergo fluorescence quenching in water, making it a viable candidate for developing a probe for detecting water in aprotic organic solvents. The analysis of mid-IR and Raman spectra of 8HQC shows the presence of seven tautomers.
Application
8-Hydroxy-2-quinolinecarboxylic acid may be used in the preparation of bis (8-hydroxyquinoline-2-carboxylato-Κ3N,O,O′) cobalt (II) trihydrate.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Determination of water content in aprotic organic solvents using 8-hydroxyquinoline based fluorescent probe.
Kim JS, et al.
Bull. Korean Chem. Soc., 27(12), 2058-2058 (2006)
Katarzyna Walczak et al.
Molecules (Basel, Switzerland), 25(7) (2020-04-09)
8-Hydroxyquinaldic acid, the end-metabolite of tryptophan, is well-known metal chelator; however, its role in humans, especially in cancer promotion and progression, has not been fully revealed. Importantly, 8-hydroxyquinaldic acid is the analog of kynurenic acid with evidenced antiproliferative activity towards
Bis (8-hydroxyquinoline-2-carboxylato-?3N,O,O') cobalt (II) trihydrate.
Okabe N and Muranishi Y.
Acta Crystallographica Section E, Structure Reports Online, 58(7), m352-m353 (2002)
A combined experimental and theoretical study on 8-hydroxy-2-quinolinecarboxylic acid.
Badoglu S and Yurdakul S.
Optics and Spectroscopy, 116(2), 196-206 (2014)
Francesco Bellia et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(70), 16690-16705 (2020-07-07)
Metal dysregulation, oxidative stress, protein modification, and aggregation are factors strictly interrelated and associated with neurodegenerative pathologies. As such, all of these aspects represent valid targets to counteract neurodegeneration and, therefore, the development of metal-binding compounds with other properties to
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