552402
1-双(4-氟苯基)甲基哌嗪
97%
别名:
1-(4,4′-二氟二苯甲基)哌嗪
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关于此项目
经验公式（希尔记法）:
C17H18F2N2
化学文摘社编号:
分子量:
288.34
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
248-476-0
Beilstein/REAXYS Number:
620754
MDL number:
Assay:
97%
产品名称
1-双(4-氟苯基)甲基哌嗪, 97%
InChI key
TTXIFFYPVGWLSE-UHFFFAOYSA-N
InChI
1S/C17H18F2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2
SMILES string
Fc1ccc(cc1)C(N2CCNCC2)c3ccc(F)cc3
assay
97%
mp
88-92 °C (lit.)
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Application
1-Bis(4-fluorophenyl)methyl piperazine may be used to synthesize 1-[bis(4-fluorophenyl)methyl]-4-[3-[(N-ethoxycarbonyl-N-phenyl)amino]-2-hydroxypropyl]piperazine and (R, S) 3-[4-(bis(4-fluorophenyl)methyl)piperazin-1-yl]dihydrofuran-2(3H)-one.
General description
1-Bis(4-fluorophenyl)methyl piperazine is formed during the synthesis of flunarizine. Its crystals exhibits monoclinic crystal system and space group P21/c.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1A
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
1-[Bis (4-fluorophenyl) methyl] piperazine.
Dayananda AS, et al.
Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials, 68(9), o2817-o2817 (2012)
Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors
Kulig K, et al.
European Journal of Medicinal Chemistry, 46(1), 183-190 (2011)
Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system.
Kimura M, et al.
Bioorganic & Medicinal Chemistry, 11(8), 1621-1630 (2003)
Y Yamanaka et al.
Archives of toxicology, 69(6), 391-396 (1995-01-01)
Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory
S Kariya et al.
Research communications in chemical pathology and pharmacology, 78(1), 85-95 (1992-10-01)
The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'-hydroxyphenyl)-2- propenyl]piperazine (M-2) and 4,4'-difluorobenzophenone (M-3) has been studied in liver microsomes of Wistar and Dark Agouti (DA) rats. Kinetic analysis demonstrated a sex difference (male > female) in the
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