方案
96%
表单
solid
旋光性
[α]20/D -49°, c = 1% in DMSO
mp
141-145 °C (lit.)
SMILES字符串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC(=O)c4ccccc4)ncnc23
InChI
1S/C17H17N5O5/c23-6-10-12(24)13(25)17(27-10)22-8-20-11-14(18-7-19-15(11)22)21-16(26)9-4-2-1-3-5-9/h1-5,7-8,10,12-13,17,23-25H,6H2,(H,18,19,21,26)/t10-,12-,13-,17-/m1/s1
InChI key
NZDWTKFDAUOODA-CNEMSGBDSA-N
Chun-Lei Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(46), 11114-11126 (2017-10-17)
Classical and systems genetics have identified wide networks of genes associated with cognitive and neurodevelopmental diseases. In parallel to deciphering the role of each of these genes in neuronal or synaptic function, evaluating the response of neuronal and molecular networks
Kevin W-H Lo et al.
Journal of tissue engineering and regenerative medicine, 10(10), 867-875 (2014-02-05)
Small molecule-based regenerative engineering is emerging as a promising strategy for regenerating bone tissue. Small molecule cAMP analogues have been proposed as novel biofactors for bone repair and regeneration and, while promising, the effect that these small molecules have on
Estelle R Simo-Cheyou et al.
Canadian journal of physiology and pharmacology, 95(8), 928-937 (2017-05-02)
cAMP has been shown to inhibit vascular smooth muscle cell proliferation and exerts a vasculoprotective effect. An upregulation of the early growth response protein-1 (Egr-1) expression has been linked with the development of atherosclerosis and intimal hyperplasia. We have recently
Shuying He et al.
The American journal of pathology, 188(6), 1374-1388 (2018-03-27)
Epithelial-to-mesenchymal transition (EMT) is a key contributor to fibroblast activation in fibrosis of multiple organs, including the intestine. Parathyroid hormone-like hormone (PTHLH) is an important factor in renal fibrosis and regulates several processes, including EMT. Herein, we investigated the role
Behzad Shariati et al.
Molecular and cellular neurosciences, 70, 54-67 (2015-11-26)
Guanine nucleotide exchange factors directly activated by cAMP (Epacs) have emerged as important signaling molecules mediating persistent hypersensitivity in animal models of inflammation, by augmenting the excitability of sensory neurons. Although Epacs activate numerous downstream signaling cascades, the intracellular signaling
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