595314
1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑
95%
别名:
1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑, 1-甲基-4-吡唑硼酸频哪醇酯
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关于此项目
经验公式（希尔记法）:
C10H17BN2O2
化学文摘社编号:
分子量:
208.07
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
Quality Level
assay
95%
form
solid
mp
59-64 °C (lit.)
SMILES string
Cn1cc(cn1)B2OC(C)(C)C(C)(C)O2
InChI
1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChI key
UCNGGGYMLHAMJG-UHFFFAOYSA-N
Application
试剂用于
用于制备
- Suzuki-Miyaura交叉偶联反应
- 酯交换反应
用于制备
- 氨基噻唑类（γ）-分泌酶调节剂
- 氨基吡啶-吲哚甲酰胺，作为骨髓增生性疾病治疗的潜在 JAK2 抑制剂
- 吡啶衍生物作为 TGF-β1 和激活素 A 信号传导抑制剂
- MK-2461 类似物作为 c-Met 激酶抑制剂治疗癌症
稳定的硼酸替代品，用于Suzuki-Miyaura钯催化交叉偶联
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
商品
Suzuki-Miyaura cross-coupling reaction is extensively used in organic chemistry, polymer science, and pharmaceutical industries.
Suzuki-Miyaura cross-coupling reaction of aryl and heteroaryl pinacol boronates for the synthesis of 2-substituted pyrimidines
Asano, S.; Kamioka, S.; Isobe, Y.
Tetrahedron, 68, 272-279 (2012)
Guopin Xu et al.
Organic letters, 7(21), 4605-4608 (2005-10-08)
[reaction: see text] The synthesis of a series of NHC building blocks that can then be incorporated into more complicated structures by palladium catalysis is reported. This approach is used for the synthesis of three amino acids containing NHC side
Thomas Lübbers et al.
Bioorganic & medicinal chemistry letters, 21(21), 6554-6558 (2011-09-20)
We herein report the discovery of a new γ-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These novel compounds demonstrate moderate to good in vitro potency in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 595314-25G | 04061833399224 |
| 595314-5G | 04061833499467 |
| 595314-1G | 04061832644059 |