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595314

1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑

Name: 1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧硼戊环-2-基)吡唑
Brand: ALDRICH

95%

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别名:

1-甲基-4-(4,4,5,5-四甲基-1,3,2-二氧杂戊硼烷-2-基)-1H-吡唑, 1-甲基-4-吡唑硼酸频哪醇酯

经验公式（希尔记法）:

C₁₀H₁₇BN₂O₂

CAS号:

761446-44-0

分子量:

208.07

MDL编号:

MFCD03789259

PubChem化学物质编号:

24881568

NACRES:

NA.22

检测方案

95%

形式

solid

mp

59-64 °C (lit.)

SMILES string

Cn1cc(cn1)B2OC(C)(C)C(C)(C)O2

InChI

1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3

InChI key

UCNGGGYMLHAMJG-UHFFFAOYSA-N

应用

稳定的硼酸替代品，用于Suzuki-Miyaura钯催化交叉偶联

试剂用于

Suzuki-Miyaura交叉偶联反应
酯交换反应

用于制备

氨基噻唑类（γ）-分泌酶调节剂
氨基吡啶-吲哚甲酰胺，作为骨髓增生性疾病治疗的潜在 JAK2 抑制剂
吡啶衍生物作为 TGF-β1 和激活素 A 信号传导抑制剂
MK-2461 类似物作为 c-Met 激酶抑制剂治疗癌症

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Direct conversion of pinacol arylboronic esters to aryl triolborates

Li, G.-Q.; et al.

Chemistry Letters (Jpn), 40, 702-704 (2011)

A versatile catalyst system for Suzuki-Miyaura cross-coupling reactions of C(sp(2))-tosylates and mesylates.

Brijesh Bhayana et al.

Organic letters, 11(17), 3954-3957 (2009-08-12)

A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed

Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.

Michael Lainchbury et al.

Journal of medicinal chemistry, 55(22), 10229-10240 (2012-10-23)

Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated

Aminothiazoles as γ-secretase modulators.

Thomas Lübbers et al.

Bioorganic & medicinal chemistry letters, 21(21), 6554-6558 (2011-09-20)

We herein report the discovery of a new γ-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These novel compounds demonstrate moderate to good in vitro potency in

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

Jason D Katz et al.

Journal of medicinal chemistry, 54(12), 4092-4108 (2011-05-26)

c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling pathways implicated in aggressive cancer phenotypes. In recent years, research into this area has highlighted c-Met as an attractive cancer drug target, triggering a number of approaches to

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Suzuki-Miyaura Cross-Coupling Reagents

The Suzuki-Miyaura cross-coupling reaction is an important and extensively used reaction in organic chemistry with applications in polymer science and in the fine chemicals and pharmaceutical industries.

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