649694
N-乙酰-D-神经氨酸-1,2,3-13C3
≥99 atom % 13C, ≥97% (CP)
别名:
唾液酸-13C3
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关于此项目
经验公式（希尔记法）:
13C3C8H19NO9
化学文摘社编号:
分子量:
312.25
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Isotopic purity:
≥99 atom % 13C
Assay:
≥97% (CP)
Mass shift:
M+3
InChI
1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11?/m0/s1/i2+1,10+1,11+1
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[13CH2][13C](O)(O[C@H]1[C@H](O)[C@H](O)CO)[13C](O)=O
InChI key
SQVRNKJHWKZAKO-JQVNYIDJSA-N
isotopic purity
≥99 atom % 13C
assay
≥97% (CP)
mp
186 °C (lit.)
mass shift
M+3
storage temp.
−20°C
Quality Level
General description
N-乙酰基-D-神经氨酸-1,2,3-13C3 是N-乙酰基-D-神经氨酸的同位素。
Application
N-乙酰基-D-神经氨酸-1,2,3-13C3 可用于通过13C NMR波谱仪定量测定无环酮、酮水合物和烯醇。它也可用于测定作为NANS缺陷患者治疗途径的唾液酸增补剂。
Packaging
该产品可以大包装形式供货，也可按需进行包装。 如需关于价格、供货形式及包装的信息，请联系稳定同位素客户服务。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Mark D Jankowski et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 238, 110336-110336 (2019-09-03)
Understanding variation in physiological traits across taxa is a central question in evolutionary biology that has wide-ranging implications in biomedicine, disease ecology, and environmental protection. Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and
Lilian Dubois et al.
Journal of medicinal chemistry, 63(15), 8231-8249 (2020-07-02)
Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy. It also enables metabolic incorporation of exogenous sialic acids, leading to autoantibodies against N-glycolylneuraminic acid in humans. Here, we identified
Thomas Klepach et al.
Journal of the American Chemical Society, 130(36), 11892-11900 (2008-08-20)
Aqueous solutions of N-acetyl-neuraminic acid (Neu5Ac, 1) labeled with (13)C at C1, C2, and/or C3 were analyzed by (13)C NMR spectroscopy to detect and quantify the acyclic forms (keto, keto hydrate, enol) present at varying pHs. In addition to pyranoses
Christel Tran et al.
Molecular genetics and metabolism reports, 28, 100777-100777 (2021-07-15)
In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability. The aim
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