产品名称
2,4-二氟嘧啶, 97%
InChI
1S/C4H2F2N2/c5-3-1-2-7-4(6)8-3/h1-2H
SMILES string
Fc1ccnc(F)n1
InChI key
JZSYSXZDIQUOGP-UHFFFAOYSA-N
assay
97%
refractive index
n20/D 1.432
bp
118-120 °C
density
1.359 g/mL at 25 °C
functional group
fluoro
Application
2,4-Difluoropyrimidine can be used as a starting material to synthesize:
- 3-Pyrimidin-4-yl-oxazolidin-2-one derivatives as mutant isocitrate dehydrogenase (IDH1) inhibitors.
- N,N′-(1,4-phenylenebis(methylene))bis(2-fluoropyrimidin-4-amine) as chemokine receptor type 4 antagonists.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
106.0 °F - closed cup
flash_point_c
41.1 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Dipyrimidine amines: a novel class of chemokine receptor type 4 antagonists with high specificity
Zhu A, et al.
Journal of Medicinal Chemistry, 53(24), 8556-8568 (2010)
Optimization of 3-pyrimidin-4-yl-oxazolidin-2-ones as orally bioavailable and brain penetrant mutant IDH1 inhibitors
Zhao Q, et al.
ACS Medicinal Chemistry Letters, 9(7), 746-751 (2018)
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