666548
7-甲基腺嘌呤
97%
别名:
6-氨基-7-甲基嘌呤, 7-甲基-7H-嘌呤-6-胺
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关于此项目
经验公式（希尔记法）:
C6H7N5
化学文摘社编号:
分子量:
149.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Assay:
97%
Form:
solid
InChI
1S/C6H7N5/c1-11-3-10-6-4(11)5(7)8-2-9-6/h2-3H,1H3,(H2,7,8,9)
SMILES string
Cn1cnc2ncnc(N)c12
InChI key
HCGHYQLFMPXSDU-UHFFFAOYSA-N
assay
97%
form
solid
mp
346-350 °C
Quality Level
Application
<ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents：</strong>7-甲基腺嘌呤可用作甲基化试剂暴露以至DNA损伤的生物标志物(Harroun et al., 2017)。</li>
</ul>
<li><strong>Biomarkers of Cigarette Smoking and DNA Methylating Agents：</strong>7-甲基腺嘌呤可用作甲基化试剂暴露以至DNA损伤的生物标志物(Harroun et al., 2017)。</li>
</ul>
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
H G Mandel et al.
Carcinogenesis, 15(7), 1393-1398 (1994-07-01)
Earlier studies showed that urine of rats which had been injected with the methylating agent N-[3H-methyl]-N-nitrosourea contained a previously undetected metabolic product, 7-[3H-methyl]adenine. This methylpurine, undoubtedly derived from alkylation of nucleic acids followed by depurination, was not labeled when 14C-methyl-labeled
Luna Laera et al.
Cancers, 11(7) (2019-07-10)
Background: Mutations in the oncosuppressor gene BReast CAncer susceptibility gene 2 (BRCA2) predispose to aggressive forms of prostate cancer which show poor response to taxane-based therapy, the standard treatment for castration-resistant, aggressive prostate cancer. Herein, we addressed the question whether
H G Mandel et al.
Carcinogenesis, 10(4), 757-762 (1989-04-01)
Relatively simple and rapid analytical procedures involving two sequential HPLC separations were developed for the isolation of methylated purines in the urine of rats administered radiolabeled methylating carcinogens. Following a dose of [3H]N-methyl-N-nitrosourea (MNU), 7-methyl-adenine (m7Gua) was detected by chromatography
Shinji Tokuda et al.
Bioscience, biotechnology, and biochemistry, 76(4), 828-830 (2012-04-10)
Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC(50) value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect
B Tudek et al.
Acta biochimica Polonica, 46(3), 785-799 (2000-03-04)
The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment of dimethylsulfate methylated DNA with NaOH creates mutagenic base derivatives leading to a
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