677175
丙酮酸-1-13C（游离酸）
≥99 atom % 13C, ≥99% (CP)
别名:
α-酮丙酸-1-13C, 2-氧丙酸-1-13C, 13C 标记丙酮酸, 丙酮酸-1-13C
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关于此项目
线性分子式:
CH3CO13CO2H
化学文摘社编号:
分子量:
89.05
NACRES:
NA.12
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
丙酮酸-1-13C（游离酸）, ≥99 atom % 13C, ≥99% (CP)
InChI
1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1
SMILES string
CC(=O)[13C](O)=O
InChI key
LCTONWCANYUPML-LBPDFUHNSA-N
isotopic purity
≥99 atom % 13C
assay
≥99% (CP)
form
liquid
bp
165 °C
mp
11-12 °C
density
1.281 g/mL at 25 °C
mass shift
M+1
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Application
超极化 13C标记的丙酮酸及其代谢产物乳酸，用于对实体肿瘤实时代谢通量进行成像，评估肿瘤对化疗、放疗和靶向mTOR药物的反应情况。
General description
Pyruvic-1-13C 是同位素标记的丙酮酸前体。
Packaging
该产品可以大包装形式供货，也可按需进行包装。 如需关于价格、供货形式及包装的信息，请联系稳定同位素客户服务。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1C
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
179.6 °F - closed cup
flash_point_c
82 °C - closed cup
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.
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