68255
4-甲基-2-氧戊酸
≥98.0% (T)
别名:
2-羰基异己酸, 4-甲基-2-氧基戊酸, α-酮异己酸, 酮亮氨酸
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关于此项目
线性分子式:
(CH3)2CHCH2COCOOH
化学文摘社编号:
分子量:
130.14
NACRES:
NA.22
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
212-435-5
Beilstein/REAXYS Number:
1701823
MDL number:
Assay:
≥98.0% (T)
Quality Level
assay
≥98.0% (T)
refractive index
n20/D 1.431
bp
82-83 °C/11 mmHg (lit.)
mp
8-10 °C
density
1.055 g/mL at 20 °C (lit.)
functional group
carboxylic acid, ketone
storage temp.
2-8°C
SMILES string
CC(C)CC(=O)C(O)=O
InChI
1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)
InChI key
BKAJNAXTPSGJCU-UHFFFAOYSA-N
General description
4-甲基-2-氧戊酸，又称为α-酮异己酸(KIC)，是亮氨酸的代谢产物。常作为合成砌块制备亮氨酸及其衍生物，并可用于胺化反应和不对称合成反应。 另外，KIC还是Strecker醛类形成的中间体。
Application
- 在人脑酮体代谢中的作用：4-甲基-2-氧戊酸参与创伤性脑损伤患者脑微透析液中酮体代谢的时间模式，说明其在大脑生化通路中的重要作用(Eiden et al., 2019)。
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
The First Highly Enantioselective Homogeneously Catalyzed Asymmetric Reductive Amination:? Synthesis of ?-N-Benzylamino Acids
Kadyrov et al.
The Journal of Organic Chemistry, 68, 4067-4070 (2003)
Intermediate role of ?-keto acids in the formation of Strecker aldehydes
Hidalgo et al.
Basic Food Chemistry, 141, 1140-1146 (2013)
Lisa S Chow et al.
American journal of physiology. Endocrinology and metabolism, 291(4), E729-E736 (2006-05-18)
Despite being an anabolic hormone in skeletal muscle, insulin's anticatabolic mechanism in humans remains controversial, with contradictory reports showing either stimulation of protein synthesis (PS) or inhibition of protein breakdown (PB) by insulin. Earlier measurements of muscle PS and PB
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 68255-5G | 04061836686390 |
| 68255-1G | 04061832755069 |