690791
α-甲基-D-苯丙氨酸
≥98.0% (HPLC)
别名:
α-Me-D-Phe-OH, (R)-(+)-2-氨基-2-甲基-3-苯基丙酸
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关于此项目
经验公式（希尔记法）:
C10H13NO2
化学文摘社编号:
分子量:
179.22
Beilstein:
5254151
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.22
方案
≥98.0% (HPLC)
表单
powder
光学纯度
ee: ≥98.0% (HPLC)
反应适用性
reaction type: solution phase peptide synthesis
应用
peptide synthesis
SMILES字符串
C[C@@](N)(Cc1ccccc1)C(O)=O
InChI
1S/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)/t10-/m1/s1
InChI key
HYOWVAAEQCNGLE-SNVBAGLBSA-N
Adverse effects of excessive consumption of amino acids.
N J Benevenga et al.
Annual review of nutrition, 4, 157-181 (1984-01-01)
C Toniolo et al.
Peptide research, 5(1), 56-61 (1992-01-01)
We have synthesized, by solution methods, and fully characterized a variety of (alpha Me)Phe derivatives and model peptides (to the pentapeptide level). The results of the solution conformational analysis, performed by using infrared absorption and 1H nuclear magnetic resonance, support
M Castillo et al.
Neurochemical research, 13(6), 547-550 (1988-06-01)
Supplementation of 5% phenylalanine plus 0.4% alpha-methylphenylalanine to the standard diet or 1% phenylalanine plus 0.08% alpha-methylphenylalanine to the drinking water produced phenylketonuria-like conditions in 5-day-old chicks. An increase of 10 to 15-fold in the phenylalanine content was observed in
Shinya Oishi et al.
Journal of medicinal chemistry, 48(3), 764-772 (2005-02-04)
Previous work has shown that incorporation of either 1-aminocyclohexanecarboxylic acid (Ac6c) or alpha-methyl-p-phosphonophenylalanine ((alpha-Me)Ppp) in the phosphotyrosyl (pTyr) C-proximal position (pY + 1 residue) of Grb2 SH2 domain binding peptides confers high affinity. The tetralin-based (S)-2-amino-6-phosphonotetralin-2-carboxylic acid (Atc(6-PO3H2)) simultaneously presents
O Greengard et al.
Neurochemical research, 9(6), 837-848 (1984-06-01)
Brain phenylalanine concentrations at plasma levels raised to that in phenylketonuric subjects were studied in rats from fetal through postnatal life. Suppression of the hepatic phenylalanine hydroxylase with alpha methylphenylalanine, and injections of age-adjusted doses of phenylalanine on the next
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