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经验公式(希尔记法):
C6H5N3O · xH2O
化学文摘社编号:
分子量:
135.12 (anhydrous basis)
PubChem Substance ID:
UNSPSC Code:
12352000
MDL number:
NACRES:
NA.22
EC Number:
219-989-7
Beilstein/REAXYS Number:
4515
产品名称
1-羟基苯并三唑 水合物, wetted with not less than 20 wt. % water, 97% dry basis
InChI key
PJUPKRYGDFTMTM-UHFFFAOYSA-N
InChI
1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
SMILES string
[H]O[H].On1nnc2ccccc12
assay
97% dry basis
form
powder
quality
wetted with not less than 20 wt. % water
composition
Water content, ~20%
reaction suitability
reaction type: Addition Reactions
mp
155-158 °C (lit.)
solubility
DMF: 0.1 g/mL, clear
Quality Level
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Application
1-羟基苯并三唑水合物作为添加剂被用于:
- 寡核苷酸偶联。
- 制备聚(乙二醇)甲醚接枝的CTS(mPEG-g-CTS)。
- 在TCNEO(四氰基环氧乙烷)改性的石墨烯上通过固相合成法合成多肽。
General description
1-羟基苯并三唑水合物(HOBt水合物)是HOBt的一种水合形式。HOBt是一种常用于化学合成的亲核性添加剂。它被广泛用作催化剂或化学计量添加剂,以加速亲核酰基取代反应,特别是酰胺化反应。此外,它还用于合成肽和核苷酸。
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 3 - Desen. Expl. 2 - Eye Irrit. 2
存储类别
4.1A - Other explosive hazardous materials
wgk
WGK 1
flash_point_f
314.6 °F
flash_point_c
157 °C
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Tetrahedron Letters, 35, 3315-3315 (1994)
T Katoh et al.
International journal of peptide and protein research, 42(3), 264-269 (1993-09-01)
3-Dimethylphosphinothioyl-2(3H)-oxazolone (MPTO) was synthesized, and its ability to effect racemization-free couplings and cyclization of a peptide and its C-terminal epimer was examined. MPTO showed good reactivity in aprotic polar solvents such as N,N-dimethylformamide (DMF) and N-methylpyrrolidone. In reactivity MPTO resembles
Synlett, 733-733 (1993)
Tetrahedron Letters, 34, 6383-6383 (1993)
Donna Wesolowski et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16582-16587 (2011-09-29)
Basic peptides covalently linked to nucleic acids, or chemically modified nucleic acids, enable the insertion of such a conjugate into bacteria grown in liquid medium and mammalian cells in tissue culture. A unique peptide, derived from human T cells, has
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